| Cat. No. |
Product Name |
Information |
| PC-25130 |
GPR40 agonist K-757
GPR40 agonist
|
GPR40 agonist K-757 is a potent, selective GPR40 (FFA1) agonist with EC50 of 2.1 nM (hGPR40). |
| PC-24882 |
HWL-088
GPR40 agonist
|
HWL-088 is a potent, selective and orally active FFAR1 (FFA1, GPR40) agonist with EC50 of 19 nM, has moderate PPARδ activity (EC50=570.9 nM). |
| PC-24589 |
DFL23916
GPR40/GPR120 agonist
|
DFL23916 is a new selective, dual GPR40 and GPR120 agonist with AC50 of 16.6 µM on human GPR120 short isoform and AC50 of 13.7 µM on human GPR40. |
| PC-24515 |
ZYDG2
GPR40 agonist
|
ZYDG2 is a potent and selective agonist for GPR40 (FFAR1) with EC50 of 41 nM and 17 nM in cell-based functional inositol 1-phosphate-ELISA assay and Ca2+ mobilization assay, respectively. |
| PC-21247 |
AH7614
GPR120 (FFAR4) inhibitor
|
AH-7614 is a potent and selective FFA4 (GPR120) antagonist with pIC50 of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. |
| PC-20870 |
GPR40 agonist AP8
GPR40 agonist
|
GPR40 agonist AP8 is a potent, selective, full allosteric agonist (AgoPAM) of GPR40 with EC50 of 0.6 nM, Emax=268%. |
| PC-20767 |
TUG-2304
FFA2 (GPR43) antagonist
|
TUG-2304 (TUG2304) is a highly potent FFA2 (GPR43) antagonist with IC50 of 3-4 nM in both cAMP and GTPγS assays. |
| PC-20441 |
Phenylacetamide 2
FFA2 agonist
|
Phenylacetamide 2 (FFA2 allosteric agonist 2) is a potent, specific and allosteric agonist of FFA2 (GPR43) with cAMP IC50 of 0.48 and 0.66 uM for hFFA2 and mFFA2, respectively. |
| PC-20438 |
2CTAP
FFA2 inverse agonist
|
2CTAP is a small molecule inverse agonist of FFA2 receptor signalling, inhibits constitutive Ca2+ levels, antagonised acetate-induced pERK1/2 and prevents damage following IRI, has no effect on cAMP. |
| PC-20434 |
MK-2305
GPR40 agonist
|
MK-2305 (MK2305) is a potent and selective partial GPR40 (FFAR1) agonist with EC50 of 6 nM (rat GPR40), stimulates glucose stimulated insulin secretion (GSIS). |
| PC-20427 |
GW9508
FFA1 agonist
|
GW9508 (GW 9508) is a potent and selective FFA1 (GPR40) agonist with pEC50 of 7.32, >1,000-fold selectivity over FFA2 and FFA3 receptors. |
| PC-20425 |
AZ13581837
GPR120 (FFAR4) agonist
|
AZ13581837 is a potent, selective GPR120 (FFAR4) agonist with EC50 of 5.2 nM and 4.3 nM for stimulation of DMR response in CHO-hGPR120/mGPR120 cells, respectively. |
