| Cat. No. |
Product Name |
Information |
| PC-35510 |
GPR40 AgoPAM AP5
GPR40 agonist
|
GPR40 AgoPAM AP5 is a potent, selective GPR40 AgoPAM (full agonist with positive allosteric modulation) with hIP1 EC50 of 0.8 nM, high selectivity over the GPR120 receptor (EC50>30 uM). |
| PC-35465 |
PBI-4050 sodium
GPR40 agonist, GPR84 antagonist
|
PBI-4050 (Setogepram, Fezagepras) sodium is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively. |
| PC-35464 |
PBI-4050
GPR40 agonist, GPR84 antagonist
|
PBI-4050 (Setogepram, Fezagepras) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively. |
| PC-35199 |
AM-6226
GPR40 agonist
|
AM-6226 (AM6226) is a potent, selective, orally bioavailable GPR40 (FFA1) full agonist with EC50 of 0.12 uM. |
| PC-63298 |
BMS-986118
GPR40 agonist
|
BMS-986118 is a potent and selective GPR40 agonist with EC50 of 70 and 63 nM for hGPR40 and mGPR40, shows no PPARγ activity (EC50>47 uM). |
| PC-63157 |
AZ1729
FFA2 agonist
|
AZ1729 is a novel direct, positive allosteric modulator of fatty acid receptor FFA2 (pEC50=6.9), selectively activates Gi signaling but lacks the capacity to activate FFA2 Gq/G11-mediated signaling pathways. |
| PC-63042 |
AM-5262
GPR40 agonist
|
AM-5262 is a potent full GPR40 (FFA1) agonist with EC50 of 81 nM. |
| PC-62591 |
GLPG0974
FFA2 antagonist
|
GLPG 0974 is a potent, selective free fatty acid receptor 2 (FFA2, GPR43) antagonist with IC50 of 95 nM. |
| PC-61079 |
DS-1558
GPR40 agonist
|
DS-1558 (DS1558) is a potent, selective, orally available GPR40 agonist with EC50 of 3.7 nM. |
| PC-60999 |
AS2575959
GPR40 agonist
|
AS2575959 is a novel potent, specific, orally available GPR40 agonist that influences glucose-dependent insulin secretion both in vitro pancreas β-cell-derived cells and in vivo. |
| PC-60642 |
ZQ-16
GPR84 agonist
|
ZQ-16 is a potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM. |
| PC-60257 |
AM-1638
GPR40 agonist
|
AM-1638 is a potent, orally bioavailable, full agonist of GPR40/FFA1 with EC50 of 0.16 uM. |
