| Cat. No. |
Product Name |
Information |
| PC-35595 |
R191
IRAK1/4 inhibitor
|
R191 (R-191) is a potent, small molecule IRAK1/4 kinase inhibitor (IRAK4 IC50=3 nM), exhibits good selectivity against a broad panel of kinases. |
| PC-35553 |
PF-06426779
IRAK4 inhibitor
|
PF-06426779 (PF06426779) is a potent, selective IRAK4 inhibitor with IC50 of 1 nM against full-length IRAK4 kinase and cell-based IC50 of 12 nM. |
| PC-35135 |
Compound 7004
IRAK2 mimetic
|
Compound 7004 (IRAK2 mimetic 7004) is a small molecule mimetic of a-helical domain of IRAK2, inhibit IL-33–induced NF-κB transcriptional activity (IC50=9.7 uM) by disrupting Myddosome formation. |
| PC-63079 |
BMS-986126
IRAK4 inhibitor
|
BMS-986126 is a potent, highly selective inhibitor of IRAK4 kinase with IC50 of 5.3 nM, displays >100-fold selective for IRAK4 over a panel of 214 kinases. |
| PC-61092 |
PF-05387252
IRAK4 inhibitor
|
A potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM). |
| PC-50002 |
CA-4948
IRAK4 inhibitor
|
Emavusertib (CA-4948) is a potent, selective and orally active IRAK4 inhibitor with IC50 of 31.7 nM. |
| PC-45740 |
PF-06650833
IRAK4 inhibitor
|
Zimlovisertib (PF-06650833) is a potent and selective IRAK4 inhibitor with IC50 of 0.2 nM. |
| PC-22433 |
TCS2210
IRAK1 inhibitor
|
TCS2210 is a selective inhibitor of IRAK1 (SPR Kd=1.76 uM) and inducer of neuronal differentiation in mesenchymal stem cells, suppresses the growth of epithelial ovarian cancer (EOC) cells. |
| PC-22315 |
JH-I-25
IRAK4 inhibitor
|
JH-I-25 is a potent, selective and orally bioavailable interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with IC50 of 20 nM. |
| PC-22269 |
GS-5718
IRAK4 inhibitor
|
GS-5718 (Edecesertib) is a potent, selective, and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor in clinical development for treatment of inflammatory diseases. |
| PC-22268 |
BIO-8169
IRAK4 inhibitor
|
BIO-8169 is a highly potent, selective, brain-penetrant and oral bioavailable IRAK4 inhibitor with IC50 of 0.23 nM, potently inhibits R848 stimulated IL-1β production with IC50 of 246 nM in HWB assays. |
| PC-22241 |
DW18134
IRAK4 inhibitor
|
DW18134 is a potent, selective IRAK4 kinase inhibitor with IC50 of 11.2 nM, inhibits the IRAK4-induced activation of NF-κB signaling. |
