| Cat. No. |
Product Name |
Information |
| PC-73131 |
HS-243
IRAK1/4 inhibitor
|
HS-243 (HS243) is a highly potent, super-selective IRAK-1/4 inhibitor with IC50 of 24/20 nM, respectively. |
| PC-72011 |
GNE-2256
IRAK4 inhibitor
|
GNE-2256 (GNE2256) is a potent, selective inhibitor of IRAK4 with biochemical Ki of 1.4 nM. |
| PC-38157 |
ND2158
IRAK4 inhibitor
|
ND2158 (ND-2158) is a highly potent and selective IRAK4 inhibitor with IC50 of 1.3 nM. |
| PC-38076 |
THZ-2-118
IRAK1 inhibitor
|
THZ-2-118 is a potent selective inhibitor of IRAK1 with IC50 of 14.2 nM. |
| PC-38073 |
JH-X-119-01
IRAK1 inhibitor
|
JH-X-119-01 is a highly potent, selective and covalent inhibitor of IRAK1 with IC50 of 9 nM. |
| PC-36036 |
HG-12-6
IRAK4 inhibitor
|
HG-12-6 is a small-molecule inhibitor that bind preferentially to unphosphorylated IRAK4 with IC50 of 165.1 nM, displays 15-fold selectivity over phosphorylated IRAK4 (IC50=2876 nM). |
| PC-35595 |
R191
IRAK1/4 inhibitor
|
R191 (R-191) is a potent, small molecule IRAK1/4 kinase inhibitor (IRAK4 IC50=3 nM), exhibits good selectivity against a broad panel of kinases. |
| PC-35553 |
PF-06426779
IRAK4 inhibitor
|
PF-06426779 (PF06426779) is a potent, selective IRAK4 inhibitor with IC50 of 1 nM against full-length IRAK4 kinase and cell-based IC50 of 12 nM. |
| PC-35135 |
Compound 7004
IRAK2-IRAK4 inhibitor
|
Compound 7004 (IRAK2 mimetic 7004) is a small molecule mimetic of a-helical domain of IRAK2, inhibit IL-33–induced NF-κB transcriptional activity (IC50=9.7 uM) by disrupting Myddosome formation. |
| PC-43498 |
IRAK-1-4 Inhibitor I
IRAK1/4 inhibitor
|
IRAK-1-4 Inhibitor I is a potent, dual inhibitor of IRAK4 and IRAK1 with IC50 of 0.2 uM and 0.3 uM, respectively. |
| PC-43455 |
IRAK inhibitor 2
IRAK4 inhibitor
|
IRAK inhibitor 2 is a potent IRAK4 inhibitor. |
| PC-43454 |
IRAK inhibitor 1
IRAK4 inhibitor
|
IRAK inhibitor 1 is a potent IRAK4 inhibitor with IC50 of 216 nM, shows little to no activity against JNK-1 and JNK-2 with IC50 of 3.801 uM and >10 uM, respectively. |
