| Cat. No. |
Product Name |
Information |
| PC-50002 |
CA-4948
IRAK4 inhibitor
|
Emavusertib (CA-4948) is a potent, selective and orally active IRAK4 inhibitor with IC50 of 31.7 nM. |
| PC-70009 |
Thymoquinone
IRAK1 inhibitor
|
Thymoquinone is an anticancer phytochemical commonly found in black cumin, exhibits anticancer activity via numerous mechanisms of action, specifically by showing selective antioxidant and oxidant activity. |
| PC-60013 |
AZ1495
IRAK4 inhibitor
|
AZ1495 is a potent, selective IRAK4 inhibitor with IC50 of 51 nM. |
| PC-45740 |
PF-06650833
IRAK4 inhibitor
|
Zimlovisertib (PF-06650833) is a potent and selective IRAK4 inhibitor with IC50 of 0.2 nM. |
| PC-22433 |
TCS2210
IRAK1 inhibitor
|
TCS2210 is a selective inhibitor of IRAK1 (SPR Kd=1.76 uM) and inducer of neuronal differentiation in mesenchymal stem cells, suppresses the growth of epithelial ovarian cancer (EOC) cells. |
| PC-22315 |
JH-I-25
IRAK4 inhibitor
|
JH-I-25 is a potent, selective and orally bioavailable interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with IC50 of 20 nM. |
| PC-22269 |
GS-5718
IRAK4 inhibitor
|
GS-5718 (Edecesertib) is a potent, selective, and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor in clinical development for treatment of inflammatory diseases. |
| PC-22268 |
BIO-8169
IRAK4 inhibitor
|
BIO-8169 is a highly potent, selective, brain-penetrant and oral bioavailable IRAK4 inhibitor with IC50 of 0.23 nM, potently inhibits R848 stimulated IL-1β production with IC50 of 246 nM in HWB assays. |
| PC-22241 |
DW18134
IRAK4 inhibitor
|
DW18134 is a potent, selective IRAK4 kinase inhibitor with IC50 of 11.2 nM, inhibits the IRAK4-induced activation of NF-κB signaling. |
| PC-21921 |
BIO-7488
IRAK4 inhibitor
|
BIO-7488 (BIO7488) is the first potent, selective, and CNS-penetrant IRAK4 inhibitor with IC50 of 0.5 nM (1 mM ATP). |
