| Cat. No. |
Product Name |
Information |
| PC-27751 |
SU3327
JNK inhibitor
|
Halicin (SU3327) is a potent, selective and substrate competitive c-Jun N-terminal kinase (JNK) inhibitor with IC50 of 0.7 uM, inhibits TNF-α stimulated phosphorylation of c-Jun with IC50 of 6.23 uM in HeLa cells. |
| PC-27744 |
JNK1 inhibitor E1
JNK1 inhibitor
|
JNK1 inhibitor E1 is a potent and selective inhibitor of JNK1 with IC50 of 2.7 nM, inhibits c-Jun phosphorylation with IC50 of <1 uM, exerts significant antifibrotic effects in a bleomycin-induced IPF mouse model and prevents TGF-β-induced epithelial-to-mesenchymal transition in vitro. |
| PC-27742 |
CDD-3013
JNK inhibitor
|
CDD-3013 is a potent and selective inhibitor of c-Jun N-terminal kinase (JNK) with Kd of 0.12/0.72/0.75 nM for JNK1/2/3 respectively, IC50 of 0.15/0.15/0.11 nM in NanoBRET intracellular target engagement assays. |
| PC-27741 |
CDD-2728
JNK inhibitor
|
CDD-2728 is a potent and selective inhibitor of c-Jun N-terminal kinase (JNK) with Kd of 0.31/3.7/1.6 nM for JNK1/2/3 respectively, IC50 of 0.61/0.57/0.53 nM in NanoBRET intracellular target engagement assays. |
| PC-27740 |
KRev-202
JNK inhibitor
|
KRev-202 is a water-soluble prodrug (49 mg/mL) of the potent and selective JNK inhibitor Tanzisertib (CC-930, CC930), prevent ischemia-induced acute kidney injury (AKI). |
| PC-27739 |
CC-90001
JNK inhibitor
|
CC-90001 (BMS-986360) is a potent c-Jun N-terminal kinase (JNK) inhibitor with IC50 of 11 nM and 31 nM for JNK1 and JNK2 respectively, inhibits cellular phosphorylation of the direct JNK substrate c-Jun (p-cJun) with IC50 of 0.48 uM. |
| PC-27738 |
Tanzisertib
JNK inhibitor
|
Tanzisertib (CC-930) is a potent, selective, ATP-competitive and orally active c-Jun N-terminal kinase (JNK) inhibitor with IC50 of 61/5/5 nM for JNK1/2/3 respectively. |
| PC-27737 |
JNK1 inhibitor 14
JNK1 inhibitor
|
JNK1 inhibitor 14 is a selective and potent inhibitor of c-Jun N-terminal kinase 1 (JNK1) with IC50 of 0.8 nM, 8.3 nM and 1.3 nM for JNK1, JNK2 and JNK3, shows 10-fold selectivity over JNK3. |
| PC-26257 |
JNK3 inhibitor 29
JNK3 inhibitor
|
JNK3 inhibitor 29 is a potent, selective c-Jun N-terminal kinase 3 (JNK3) with IC50 of 5 nM, 15-fold and 75-fold selective over JNK2 and JNK1. |
| PC-26256 |
JMH021
JNK3 inhibitor
|
JMH021 is a potent, isoform-selective JNK3 inhibitor with IC50 of 2.0 nM, 30- to 150-fold greater potency against JNK3 compared to JNK1 or JNK2. |
| PC-26255 |
JNK3 inhibitor 14bg
JNK3 inhibitor
|
JNK3 inhibitor 14bg is a potent, selective c-Jun N-terminal kinase 3 (JNK3) with IC50 of 0.26 nM, has 72-fold selectivity over JNK2, 84-fold over JNK1, and 194-fold over p38α. |
| PC-26249 |
SR-3737
p38/JNK3 inhibitor
|
SR-3737 is a potent JNK3 and p38 inhibitor with IC50 of 12 nM and 3 nM respectively. |
