| Cat. No. |
Product Name |
Information |
| PC-38906 |
CID661578
MNK2 inhibitor
|
CID661578 is a potent inducer of β-cell regeneration, targets MAP kinase-interacting serine/threonine kinase 2 (MNK2). |
| PC-72233 |
ETC-168
MNK inhibitor
|
ETC-168 (ETC168) is a potent, selective MNK kinase inhibitor with biochemical IC50 of 23 and 43 nM against MNK1 and MNK2, respectively. |
| PC-72232 |
DS12881479
MNK1 inhibitor
|
DS12881479 (DS 12881479) is a novel potent, selective inhibitor of MAPK-interacting kinase 1 (Mnk1) with IC50 of 21 nM, stabilizes the autoinhibited state of Mnk1. |
| PC-63366 |
ETC-206
MNK inhibitor
|
ETC-206 (Tinodasertib, ETC-1907206) is a potent, selective MNK1/2 inhibitor with IC50 of 64/86 nM, inhibits eIF4E phosphorylation inhibition in HeLa cell line with IC50 of 321 nM. |
| PC-63078 |
MNKI-19
MNK inhibitor
|
MNKI-19 is a potent and dual-specific Mnk inhibitor with Ki of 186 nM and 68 nM for Mnk1 and Mnk2, respectively. |
| PC-63077 |
MNKI-85
MNK2 inhibitor
|
MNKI-85 is a potent and selective Mnk2 inhibitor with Ki of 31 nM, displays no inhibitory activities against Mnk1, CDK2A, CDK9T, and CDK4D. |
| PC-63076 |
QL-X-138
BTK/MNK inhibitor
|
QL-X-138 is a selective and potent BTK/MNK dual kinase inhibitor with IC50 of 8, 107.4, and 26 nM for BTK, MNK1, and MNK2, respectively. |
| PC-63075 |
MNK-IN-54
BCR-ABL1/MNK inhibitor
|
MNK-IN-54 is a potent, orally bioavailable dual MNK1/2 and BCR-ABL1 inhibitor with IC50 of 20/10/200/10 nM for Abl T315I/ wt Abl/MNK1/MNK2, respectively. |
| PC-63074 |
MNKI-8e
MNK2 inhibitor
|
MNKI-8e (MNK inhibitor 8e) is a potent, selective MNK inhibitor that inhibits Mnk2 with Ki of 0.37 uM, displays >34-fold and 4-fold over CDK2 (Ki>10 uM) and CDK9 (Ki=1.66 uM). |
| PC-62896 |
BAY 1143269
MNK1 inhibitor
|
BAY 1143269 is a potent, selective, orally bioavailable inhibitor of MNK1 with enzyme IC50 of 40 nM at 2 mM ATP. |
| PC-62742 |
SEL-201
MNK inhibitor
|
SEL-201 (SLV-2436, SEL201-88) is a novel potent, selective, ATP-competitive and oral MNK1/2 inhibitor with IC5010.8/5.4 nM, respectively. |
| PC-61145 |
MNK inhibitor 9
MNK inhibitor
|
MNK inhibitor 9 is a potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor with IC50 of 3 nM for both, with no activity aginst CDK1/2 (IC50>25 uM). |
