| Cat. No. |
Product Name |
Information |
| PC-20991 |
EVP4593
nSOC inhibitor
|
EVP4593 (EVP-4593) is an inhibitor of PMA/PHA-induced NF-κB pathway activation with IC50 of 9 nM, inhibits storeoperated calcium (Ca2+) entry (SOC) pathway in huntington's disease (HD) neurons. |
| PC-49360 |
IT848
NF-κB inhibitor
|
IT848 (IT-848) is a potent and specific small molecule NF-κB inhibitor, decreases the affinity of NF-κB all five subunits (Rel A, Rel B, c-Rel, p50 and p52) to their DNA binding sites and disrupts downstream biological events. |
| PC-47045 |
CRL1101
RelA inhibitor
|
CRL1101 is a small-molecule inhibitor of RelA, binds specifically to RelA (KD=2.3 uM, MST assays) and blockes RelA nuclear translocation in breast cancer cells. |
| PC-47044 |
DHMEQ
NF-κB inhibitor
|
DHMEQ (dehydroxymethylepoxyquinomicin) is an NF-κB inhibitor, inhibits TNF-α-induced activation of NF-κB, and inhibits the TNF-α-induced nuclear accumulation of p65, a component of NF-κB. |
| PC-38805 |
ML236
NF-κB inhibitor
|
ML236 is a potent, B-cell specific NF-κB inhibitor with IC50 of 35 nM, selective for the NF-κB pathway induced by PKC activators (phorbol myristic acetate/ionomycin) and selective for B-cells. |
| PC-38798 |
ML029
NF-κB inhibitor
|
ML029 is a potent and selective probe inhibiting the PKC-initiated NF-kappaB pathway with IC50 of 67 nM. |
| PC-45990 |
(R)-(-)-Ibuprofen
|
An enantiomer of Ibuprofen that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids. |
