| Cat. No. |
Product Name |
Information |
| PC-60767 |
JNJ-42253432
P2X7 antagonist
|
JNJ-42253432 is a potent, selective, CNS-penetrant P2X7 antagonist with pKi of 9.1 and 7.9 for rat and huamn P2X7 channel, respectively. |
| PC-70094 |
AZD-9056
P2X7 antagonist
|
AZD-9056 is a potent, selective, orally bioavailable P2X7 receptor antagonist, inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM. |
| PC-45634 |
AZD-9056 hydrochloride
P2X7 antagonist
|
AZD-9056 hydrochloride is a potent, selective, orally bioavailable P2X7 receptor antagonist; inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM. |
| PC-45846 |
A-740003
P2X7 antagonist
|
A-740003 (A740003) is a potent, selective, competitive P2X7 receptor antagonist with IC50 of 40 nM and 18 nM for hP2X7 and rP2X7, respectively. |
| PC-42169 |
A-804598
P2X7 antagonist
|
A-804598 is a potent, selective and competitive P2X7 receptor antagonist with IC50 of 10, 9 , and 11 nM for rat, mouse, and human P2X7, respectively. |
| PC-25573 |
HW091077
P2X3 antagonist
|
HW091077 is a potent, selective P2X3 receptor (P2X3R) antagonist with IC50 of 17 nM, shows balanced selectivity versus P2X2/3 (IC50=190 nM). |
| PC-25572 |
UB-MBX-46
P2X7 antagonist
|
UB-MBX-46 is a potent, selective and allosteric antagonist of human P2X7 receptor (hP2X7R) antagonist with IC50 of 0.514 nM, 40.6 nM and 4.52 nM for human, rat and mouse P2X7R respectively. |
| PC-25029 |
Relicpixant
P2X3 antagonist
|
Relicpixant is a potent, selective P2X3 receptor antagonist. |
| PC-24035 |
Brilliant Blue G
P2X7 antagonist
|
Brilliant Blue G-250 is a dye commonly used for the visualization of proteins separated by SDS-PAGE, also is a highly selective P2X7 receptor antagonist. |
| PC-24034 |
ITH15004
P2X7 antagonist
|
ITH15004 is potent, selective, and BBB-permeable antagonist of ATP-gated P2X7 purinergic receptor (P2X7) with IC50 of 9 uM. |
| PC-22910 |
AZ11645373
P2X7 antagonist
|
AZ11645373 is a selective and potent antagonist of human P2X7 receptor, inhibits ATP-mediated release of IL-1β in LPS-stimulated THP-1 monocytes with Kb of 92 nM. |
| PC-22645 |
GSK1482160
P2X7 NAM
|
GSK1482160 is an orally available allosteric P2X7 receptor negative allosteric modulator (NAM). |
