| Cat. No. |
Product Name |
Information |
| PC-45634 |
AZD-9056 hydrochloride
P2X7 antagonist
|
AZD-9056 hydrochloride is a potent, selective, orally bioavailable P2X7 receptor antagonist; inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM. |
| PC-45846 |
A-740003
P2X7 antagonist
|
A-740003 (A740003) is a potent, selective, competitive P2X7 receptor antagonist with IC50 of 40 nM and 18 nM for hP2X7 and rP2X7, respectively. |
| PC-42169 |
A-804598
P2X7 antagonist
|
A-804598 is a potent, selective and competitive P2X7 receptor antagonist with IC50 of 10, 9 , and 11 nM for rat, mouse, and human P2X7, respectively. |
| PC-22910 |
AZ11645373
P2X7 antagonist
|
AZ11645373 is a selective and potent antagonist of human P2X7 receptor, inhibits ATP-mediated release of IL-1β in LPS-stimulated THP-1 monocytes with Kb of 92 nM. |
| PC-22645 |
GSK1482160
P2X7 NAM
|
GSK1482160 is an orally available allosteric P2X7 receptor negative allosteric modulator (NAM). |
| PC-22526 |
NP-1815-PX sodium
P2X4 antagonist
|
NP-1815-PX sodium is a potent, selective P2X4 receptor (P2X4R) antagonist, inhibits P2X4R-mediated [Ca2+]i increase in hP2X4R-1321N1 cells with IC50 of 0.26 μM. |
| PC-22525 |
NP-1815-PX
P2X4 antagonist
|
NP-1815-PX is a potent, selective P2X4 receptor (P2X4R) antagonist, inhibits P2X4R-mediated [Ca2+]i increase in hP2X4R-1321N1 cells with IC50 of 0.26 μM. |
| PC-21904 |
A438079 hydrochloride
P2X7 inhibitor
|
A438079 hydrochloride is a selective, competitive P2X7 receptor antagonist with pIC50 of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line. |
| PC-21903 |
A438079
P2X7 inhibitor
|
A438079 is a selective, competitive P2X7 receptor antagonist with pIC50 of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line. |
| PC-20742 |
DT-0111
P2X2/3 antagonist
|
DT-0111 (DT0111) is a selective and effective, water-soluble antagonist at P2X2/3R, does not activate or block P2YR, inhibits ATP-induced current in nodose ganglionic cells with IC50 of 0.3 uM. |
| PC-20738 |
Filapixant
P2X3 antagonist
|
Filapixant (BAY1902607) is a potent, selective P2X3 receptor antagonist, shows a substantially higher in vitro selectivity for P2X3 over P2X2 when compared with Eliapixant (BAY1817080, Cat# PC-72754). |
