| Cat. No. |
Product Name |
Information |
| PC-62755 |
RO-51
|
RO-51 is a potent, selective and drug-like dual P2X3 and P2X2/3 antagonist with pIC50 of 8.7 and 8.3, respectively.. |
| PC-62754 |
AF-353
|
AF-353 (RO-4) is a potent, selective and drug-like dual P2X3 and P2X2/3 antagonist with pIC50 of 8.0 and 7.1, respectively.. |
| PC-61827 |
AF-792
|
AF-792 (RO-5) is a novel selective P2X3 and P2X2/3 antagonist with pIC50 of 8.2 and 7.9 respectively, with no inhibition at other P2X receptors. |
| PC-61622 |
JNJ-54175446
|
JNJ-54175446 is a potent and selective, brain penetrant P2X7 ion channel antagonist with pIC50 of 8.46 and 8.81 for hP2X7 and rP2X7, respectively. |
| PC-61123 |
JNJ 54166060
|
A potent, selective and orally bioavailable P2X7 receptor with IC50 of 4 nM and 115 nM for hP2X7 and rP2X7, respectively. |
| PC-60767 |
JNJ-42253432
|
A potent, selective, CNS-penetrant P2X7 antagonist with pKi of 9.1 and 7.9 for rat and huamn P2X7 channel, respectively. |
| PC-42169 |
A-804598
|
A potent, selective and competitive P2X7 receptor antagonist with IC50 of 10, 9 , and 11 nM for rat , mouse, and human P2X7, respectively. |
