| Cat. No. |
Product Name |
Information |
| PC-61575 |
CE-224535
P2X7 antagonist
|
CE-224535 (PF-04905428) is a potent and selective P2X7 receptor antagonist with IC50 of 1.4 nM (inhibition of the release of lL-1b from monocytes stimulated by ATP). |
| PC-61379 |
Gefapixant
P2X3 antagonist
|
Gefapixant (AF-219, MK-7264) is an orally active, small molecule antagonist of P2X3-containing receptor with IC50 of 30 nM (hP2X3 homotrimer) and 100-250 nM (hP2X2/3 heterotrimer). |
| PC-61123 |
JNJ 54166060
P2X7 antagonist
|
A potent, selective and orally bioavailable P2X7 receptor with IC50 of 4 nM and 115 nM for hP2X7 and rP2X7, respectively. |
| PC-60767 |
JNJ-42253432
P2X7 antagonist
|
JNJ-42253432 is a potent, selective, CNS-penetrant P2X7 antagonist with pKi of 9.1 and 7.9 for rat and huamn P2X7 channel, respectively. |
| PC-70094 |
AZD-9056
P2X7 antagonist
|
AZD-9056 is a potent, selective, orally bioavailable P2X7 receptor antagonist, inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM. |
| PC-45634 |
AZD-9056 hydrochloride
P2X7 antagonist
|
AZD-9056 hydrochloride is a potent, selective, orally bioavailable P2X7 receptor antagonist; inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM. |
| PC-45846 |
A-740003
P2X7 antagonist
|
A-740003 (A740003) is a potent, selective, competitive P2X7 receptor antagonist with IC50 of 40 nM and 18 nM for hP2X7 and rP2X7, respectively. |
| PC-42169 |
A-804598
P2X7 antagonist
|
A-804598 is a potent, selective and competitive P2X7 receptor antagonist with IC50 of 10, 9 , and 11 nM for rat, mouse, and human P2X7, respectively. |
| PC-27056 |
BTFA
P2X1 receptor inhibitor
|
BTFA is a specific small molecule P2X1 receptor inhibitor, binds to the top of the central vestibule and inhibits cation flux in a dose-dependent manner, inhibits the mixed-cation current of the mP2X1 receptor with IC50 of 4.3 uM. |
| PC-26954 |
EVT‑401
P2X7R antagonist
|
EVT-401 is a potent, highly selective human P2X7 receptor (P2X7R) antagonist with Ki of 7.6 nM in competitive binding assays. |
| PC-26328 |
Funopixant
P2X3 antagonist
|
Funopixant is a potent, selective P2X3 receptor antagonist with IC50 of 32.45 nM for hP2X3. |
| PC-26169 |
PSB-OR-2020
P2X4 antagonist
|
PSB-OR-2020 is a potent, selective P2X4 receptor antagonist, inhibits ATP-induced Ca2+ influx by in 1321N1 astrocytoma cells stably transfected with the human P2X4 receptor with IC50 of 6.32 nM, >300-fold selective over P2X1, P2X2, P2X3, and P2X7. |
