| Cat. No. |
Product Name |
Information |
| PC-27721 |
GR63799
EP3 agonist
|
GR63799X (GR63799) is a potent and selective prostanoid EP3 receptor agonist. |
| PC-27720 |
DG041
EP3 antagonist
|
DG-041 (DG041) is a potent and selective prostanoid EP3 receptor antagonist with IC50 of 4.6 nM and 8.1 nM in binding and FLIPR assay, respectively. |
| PC-27537 |
HTL0039732
EP4 antagonist
|
HTL0039732 is a potent, selective and orally bioavailable E-type prostanoid receptor 4 (EP4) antagonist, blocks signalling through prostaglandin E2 receptor EP4, enhances immune response against tumours that typically resist current immunotherapies. |
| PC-24436 |
ACT-1002-4271
EP2/EP4 antagonist
|
ACT-1002-4271 is a potent, selective dual EP2/EP4 antagonist with IC50 of 6 nM/3 nM for hEP2/hEP4 respectively in cAMP-based activity assays. |
| PC-35836A |
PGN 9856-isopropyl ester
EP2 receptor agonist
|
PGN 9856-isopropyl ester is the isopropyl ester, which is a potent, selective prostaglandin EP2 receptor agonist with pKi of > 8.3. |
| PC-35836D |
d4-PGN9856
EP2 receptor agonist
|
d4-PGN9856 is a d4-labelled PGN-9856, which is a potent, selective prostaglandin EP2 receptor agonist. |
| PC-21314 |
AZD1981
DP2 (CRTh2) inhibitor
|
AZD1981 is a potent and selective CRTh2 (DP2) antagonist with pIC50 of 8.4 (human recombinant DP2), with no significant affinity towards recombinant human DP1 receptors. |
| PC-20915 |
Selexipag
IP receptor agonist
|
Selexipag (NS-304) is an orally available, long-acting nonprostanoid prostacyclin receptor (IP receptor) agonist, the prodrug of the active form of MRE-269. |
| PC-20856 |
LY3127760
EP4 antagonist
|
LY3127760 is a potent, selective prostaglandin E4 (EP4) receptor antagonist with binding Ki of 58 nM (hEP4) and cAMP IC50 of 5.6 nM. |
| PC-20854 |
CR6086
EP4 antagonist
|
CR6086 (Vorbipiprant) is a potent, selective prostaglandin E2 receptor 4 (EP4) antagonist with Ki of 16.6 nM (hEP4 receptor), inhibits PGE2-stimulated cAMP production with IC50 of 22 nM. |
| PC-20853 |
ONO-4578
EP4 antagonist
|
ONO-4578 (BMS-986310) is a potent, highly selective EP4 antagonist, potently inhibits the PGE2-induced cAMP production in CHO cells expressing mouse and human EP4 receptors with single-digit nM IC50. |
| PC-20722 |
SQ29548
TXA2R antagonist
|
SQ29548 (SQ-29,548) is a potent and specific antagonist of TXA2 receptor (TXA2R) with binding Ki value of 4.1 nM, blocks thromboxane-prostanoid receptor signaling to inhibit serotonin-induced vasoconstriction. |
