| Cat. No. |
Product Name |
Information |
| PC-36059 |
MF-766
EP4 antagonist
|
MF-766 (MF766) is a highly potent and selective EP(4) antagonist with binding Ki of 0.23 nM, displays no significant affinity (>7000-fold selectivity) against other PG receptors (IC50>1500 nM). |
| PC-36058 |
BGC20-1531
EP4 antagonist
|
BGC20-1531 (PGN-1531, AP 1531) is a potent, selective prostanoid EP receptor EP antagonist, exhibits high affinity at recombinant human EP4 receptors expressed in cell lines (pKB=7.6) and native EP4 receptors in human cerebral and meningeal artery (pKB=7.6-7.8). |
| PC-36057 |
BAY1316957
EP4 antagonist
|
BAY1316957 (BAY 1316957) is a highly potent, selective, orally available human prostaglandin E2 receptor subtype 4 (hEP4-R) antagonist with IC50 of 15.3 nM. |
| PC-35910 |
AZ12204657
GPR44 antagonist
|
AZ12204657 (AZ-12204657) small-molecule GPR44 antagonist, displaces the binding of [3H]PGD2 from membranes of HEK293 cells transfected with human recombinant GPR44 with IC50 of 2.5 nM. |
| PC-35836 |
PGN-9856
EP2 receptor agonist
|
PGN-9856 (PGN9856) is a novel potent, selective prostaglandin EP2 receptor agonist with pKi of > 8.3, shows high selectivity over EP1 , EP3 , EP4 , DP, FP, IP and TP receptors. |
| PC-35786 |
TG8-69
EP2 antagonist
|
TG8-69 is a peripherally restricted, highly potent, selective, aqueous-soluble EP2 antagonist with Kb of 48.5 nM. |
| PC-35542 |
ASP7657
EP4 antagonist
|
ASP7657 (ASP-7657) is a potent, selective, orally active prostaglandin EP4 receptor antagonist with Ki values of 6.02 nM and 2.21 nM for rat and human EP4 receptors, resepctively. |
| PC-35509 |
MK-8318
CRTH2 inhibitor
|
MK-8318 (MK8318) is a potent, selective, orally available CRTh2 receptor antagonist with Ki of 5 nM, shows nM potency in functional assay (cAMP IC50=8 nM, β-Arrestin IC50=3.5 nM. |
| PC-35403 |
Omidenepag Isopropyl
EP2 agonist
|
Omidenepag Isopropyl (DE-117, OMDI) is the prodrug of Omidenepag, which is a potent, selective agonist human EP2 receptor. |
| PC-35402 |
Omidenepag
EP2 agonist
|
Omidenepag (UR-7276) is a potent, selective agonist human EP2 receptor with binding IC50/EC50 of 10/1.7 nM, >500-fold selectivity over EP1, EP3 and EP4 receptors. |
| PC-35353 |
RO1138452
IP receptor inhibitor
|
RO1138452 is a potent, selective antagonist of prostacyclin receptor (IP receptor), inhibits carbaprostacylin-stimulated c-AMP accumulation in human SH-SY5Y neuroblastoma cells with pKb of 8.8. |
| PC-35221 |
CR6086 sodium
EP4 antagonist
|
CR6086 sodium (CR-6086) is a potent, selective prostaglandin E2 receptor 4 (EP4) antagonist with Ki of 16.6 nM (hEP4 receptor), inhibits PGE2-stimulated cAMP production with IC50 of 22 nM. |
