| Cat. No. |
Product Name |
Information |
| PC-20893 |
WNTinib
Wnt/β-catenin inhibitor
|
WNTinib is a multi-kinase inhibitor with specificity against β-catenin (CTNNB1) mutant hepatocellular carcinoma, harnesses the KIT/MAPK/EZH2 pathway, shows durable and selective transcriptional repression of mutant β-catenin/Wnt targets through nuclear translocation of the EZH2 transcriptional repressor. |
| PC-35711 |
DK419
Wnt/β-catenin inhibitor
|
DK419 (DK-419) a potent, orally acitve inhibitor of Wnt/β-catenin signaling with IC50 of 0.19 uM in Wnt3A-stimulated TOPFlash assays. |
| PC-35498 |
PAWI-2
Wnt inhibitor
|
PAWI-2 is a small molecule inhibitor targets both Wnt signaling and ATM/p53, potently inhibits Wnt transcription (IC50=11 nM) and p53 transcription (EC50=1.9 nM). |
| PC-35020 |
Box5
Wnt5a inhibitor
|
Box5 is a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist. |
| PC-42972 |
Cardiogenol C hydrochloride
Wnt activator
|
Cardiogenol C is a small cell-permeable molecule that selectively and efficiently induce mouse embryonic stem cells (ESCs) to differentiate into cardiomyocytes with EC50 of 0.1 uM, activates Wnt signaling pathway. |
| PC-62447 |
Cardionogen 1
Wnt inhibitor
|
Cardionogen 1 (CDNG1) is a small molecule that promotes cardiomyocyte generation by modulating Wnt signaling. |
| PC-62446 |
Cardionogen 2
Wnt inhibitor
|
Cardionogen 2 (CDNG2) is a small molecule that promotes cardiomyocyte generation by modulating Wnt signaling. |
| PC-62039 |
Wntepane 1
Vangl1 modulator
|
Wntepane 1 is a small-molecule activator of the Wnt pathway that modulates the van-Gogh-like receptor 1 (Vangl1), activates Wnt signaling with EC50 of 1.8 uM in the reporter gene assay. |
| PC-61759 |
Foxy-5
Wnt5A agonist
|
Foxy-5 (formyl-Met-Asp-Gly-Cys-Glu-Leu) is a Wnt5A mimicking hexapeptide that inhibits breast cancer metastasis in vivo by targeting cell motility. |
| PC-70264 |
QS-11
ARFGAP1 inhibitor
|
QS-11 (QS11) is a small molecule inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) with Kd of 620 nM, synergizes the Wnt/beta-catenin signaling. |
| PC-70223 |
Prodigiosin
Wnt/β-catenin inhibitor
|
Prodigiosin is a natural red pigment produced by numerous bacterial species, has exhibited promising anticancer activity. |
| PC-45698 |
JW74
Wnt inhibitor
|
JW74 is an efficient and specific inhibitor of the canonical Wnt signaling with IC50 of 0.79 uM in ST-Luc assay. |
