| Cat. No. |
Product Name |
Information |
| PC-49410 |
Nirogacestat
γ-secretase inhibitor
|
Nirogacestat (PF-03084014) is a potent, noncompetitive, and selective gamma-secretase inhibitor, reduces amyloid-beta (Abeta) production with in vitro IC50 of 1.2 nM (whole-cell assay) to 6.2 nM (cell-free assay). |
| PC-72151 |
RO7185876
γ-secretase modulator
|
RO7185876 (RO 7185876) is a potent and selective γ-secretase modulator (GSM) with IC50 Aβ42 of 2 nM. |
| PC-36082 |
BMS-932481
γ-secretase modulator
|
BMS-932481 (BMS932481) is a potent, selective, orraly active γ-secretase modulator (GSM), shows selectivity for Aβ40 and Aβ42 reduction (IC50=6.6 nM) while sparing total Aβ levels both in vitro and in vivo. |
| PC-35276 |
LY900009
γ-secretase inhibitor
|
LY900009 (LY-900009) is an orally active small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein, inhibits Notch signalling in tumour cell lines and endothelial cells with IC50 of 0.005-20 nM. |
| PC-35198 |
BPN-15606
γ-secretase modulator
|
BPN-15606 (BPN15606) is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 by SHSY5Y neuroblastoma cells with IC50 of 7 nM. |
| PC-35113 |
GSM-1
γ-secretase modulator
|
GSM-1 (GSM1) is a γ-secretase modulator that directly targets the transmembrane domain (TMD) 1 of presenilin 1, shows potent Aβ42-lowering effect (IC50=0.348 uM) in a cell-based assay. |
| PC-43337 |
DAPT
γ-secretase inhibitor
|
DAPT (GSI-IX, GSI IX) is a small molecule γ-secretase inhibitor that reduces the total beta-amyloid peptide (Aβ) production with IC50 of 20 nM in HEK 293 cells, without affecting protein secretion. |
| PC-43045 |
Z-Ile-Leu-aldehyde
γ-secretase inhibitor
|
Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) is a potent gamma-secretase and Notch signaling inhibitor. |
| PC-42810 |
RO4929097
γ-secretase inhibitor
|
RO4929097 (RG 4733) is a potent, selective, orally active γ-secretase inhibitor with IC50 of 4 nM, inhibits Notch processing in the Notch cell-based reporter assay with IC50 of 5 nM. |
| PC-62921 |
MRK-560
γ-secretase inhibitor
|
MRK-560 is a potent, brain-penetrant and orally bioavailable γ-secretase inhibitor that inhibits proteolytic cleavage of APP over the Notch pathway. |
| PC-62920 |
AZ 4800
γ-secretase modulator
|
AZ 4800 is a potent γ-secretase modulator that reduces Aβ40 and Aβ42 levels in HEK/APPswe cells with IC50 of 26 nM and 60 nM, also decreases Aβ39, whereas increases both Aβ37 and Aβ38.. |
| PC-62913 |
GSM-2
γ-secretase modulator
|
GSM-2 is a second-generation γ-secretase modulator (GSM) that only decreases Aβ42 (IC50=65.2 nM), while inversely increasing Aβ38 and having no effect on β-CTF and Aβ40 levels. |
