| Cat. No. |
Product Name |
Information |
| PC-42053 |
Semagacestat
γ-secretase inhibitor
|
Semagacestat (LY-450139) is a potent γ-secretase inhibitor that inhibits β-amyloid Aβ42, Aβ38 and Aβ40 with IC50 of 10.9, 12 and 12.1 nM, respectively. |
| PC-45860 |
LY-411575
γ-secretase inhibitor
|
LY-411575 is a potent γ-secretase inhibitor that has an IC50 value of 119 pM for reduction of Aβ levels in APP-transfected cell lines. |
| PC-45626 |
L-685458
γ-secretase inhibitor
|
L-685458 (L-685,458) is a potent inhibitor of amyloid β-protein precursor gamma-secretase activity (IC50=14 nM). |
| PC-24101 |
RO-02
γ‐secretase modulator
|
RO-02 (RO5434400) is a small molecule γ-secretase modulator (GSM), lowers Aβ42 species in HEK293 cells stably expressing the APPsw mutant (HEK293/sw) with IC50 of 12 nM, lowers Aβ40 and Aβ42 generation. |
| PC-24100 |
RO5254601
γ‐secretase modulator
|
RO5254601 is a novel indole-type γ-secretase modulator (GSM) with IC50 (Aβ42) of 380 nM in HEK293/sw cells, increases the production of Aβ38. |
| PC-24099 |
RO7019009
γ‐secretase modulator
|
RO7019009 is a small molecule γ‐secretase modulator, efficiently reduces the levels of Aβ42 (IC50=14 nM) and Aβ40 secreted by HEK293/sw cell, effectively lowers Aβ43 of all Aβ43‐generating mutants. |
| PC-23877 |
CHF5074
γ-secretase modulator
|
Itanapraced (CHF5074) is a selective, orally active gamma-secretase (γ-secretase) modulator, reduces Abeta42 and Abeta40 secretion with IC50 of 3.6 and 18.4 uM in human neuroglioma cell line expressing Swedish mutated form of amyloid precursor protein (H4swe). |
| PC-22499 |
GSM-776890
γ-secretase modulator
|
UCSD-776890 (UCSD-776890) is a potent, selective γ-secretase modulator with Aβ42 IC50 of 4.2 nM, Aβ40 IC50 of 80 nM, also shows EC50 of 18 nM for potentiating Aβ38 secretion. |
| PC-22498 |
NGP-555
γ-secretase modulator
|
NGP-555 (NGP555) is a potent, selective γ-secretase modulator with Aβ42 IC50 of 10 nM. |
| PC-22497 |
E-2212
γ-secretase modulator
|
E-2212 is a potent, selective γ-secretase modulator with Aβ42 IC50 of 7 nM. |
| PC-22490 |
Dibenzazepine
γ-secretase inhibitor
|
Dibenzazepine (YO-01027, DBZ) is a potent γ-secretase inhibitor with IC50 values of 2.92 and 2.64 nM for Notch and APPL cleavage, respectively, exhibits potent inhibiting activity against SPP in vitro and in vivo through the interaction of Val223 in SPP. |
| PC-60155 |
γ-secretase modulator 14a
|
A potent, selective, orally active γ-secretase modulator with Aβ42 IC50 of 39 nM. |
