| Cat. No. |
Product Name |
Information |
| PC-63316 |
LAF389
MetAP1/2 inhibitor
|
LAF389 is a potent methionine aminopeptidase (MetAP) inhibitor with IC50 of 800 nM for MetAP-2, inhibits both MetAP1 and 2, potently inhibits HUVEC proliferation with IC50 of 20 nM. |
| PC-63315 |
JNJ-4929821
MetAP2 inhibitor
|
JNJ-4929821 is a potent, reversible methionine aminopeptidase-2 (MetAP-2) inhibitor with IC50 of 8 nM.. |
| PC-63314 |
TNP-470
MetAP2 inhibitor
|
TNP-470 (AGM-1470) is a specific, rreversible MetAP-2 inhibitor and and annti-angiogenic compound, inhibits endothelial cell proliferation and angiogenesis. |
| PC-63184 |
ZGN-1061
MetAP-2 inhibitor
|
ZGN-1061 (Aclimostat) is a novel potent, selective Methionine aminopeptidase 2 (MetAP2) inhibitor being investigated for treatment of diabetes and obesity. |
| PC-61441 |
Beloranib
MetAP2 inhibitor
|
Beloranib (ZGN-440) is an analog of the natural compound Fumagillin that functions as a highly potent methionine aminopeptidase 2 (MetAP2) inhibitor. |
| PC-60511 |
Firibastat
Aminopeptidase A inhibitor
|
Firibastat (QGC 001, RB 150) is a potent, orally active, centrally acting aminopeptidase inhibitor, the prodrug of the specific and selective aminopeptidase A inhibitor EC33. |
| PC-60469 |
CHR 2863
Aminopeptidase inhibitor
|
CHR 2863 is a potent, orally available hydrophobic aminopeptidase inhibitor that structurally mimics the aminopeptidase inhibitor Tostedostat. |
| PC-70071 |
Tosedostat
Aminopeptidase inhibitor
|
Tosedostat (CHR-2797, CHR2797) is a potent, orally bioavailable aminopeptidases inhibitor with IC50 of 150, 220 and 100 nM for PuSA, aminopeptidase N and leucine aminopeptidase, respectively. |
| PC-42712 |
DG051
LTA4H inhibitor
|
DG051 (DG-051) is a potent, selective LTA4H (Leukotriene A4 hydrolase) inhibitor (IC50/Kd=47/25 nM) of leukotriene B4 biosynthesis. |
| PC-23921 |
BDM_76464
IRAP inhibitor
|
BDM_76464 is a potent, selective inhibitor of insulin-regulated aminopeptidase IRAP with IC50 of 23 nM, has >25-fold selecive over ERAP1 and ARAP2. |
| PC-23920 |
BDM_92499
IRAP inhibitor
|
BDM_92499 is a potent, selective inhibitor of insulin-regulated aminopeptidase IRAP with IC50 of 3.4 nM has >150-fold selecive\ity over ERAP1 and ARAP2. |
| PC-23105 |
CQ80
PEPD/XPNPEP1 inhibitor
|
CQ80 is a dual inhibitor of the Xaa-Pro-cleaving M24B aminopeptidases PEPD and XPNPEP1 with IC50 of 0.91 and 43 uM respectively, selectively activates the CARD8 inflammasome. |
