| Cat. No. |
Product Name |
Information |
| PC-28293 |
UBASHIN-5
UBASH3B inhibitor
|
UBASHIN-5 (LIT-14-132) is a small-molecule inhibitor targeting UBASH3B 2HP domain, disrupts mitotic localization of UBASH3B and Aurora B, seletively induces arrest and cell death during mitosis without toxicity to normal cells, selectively suppresses breast and colon tumor growth in vivo. |
| PC-28292 |
UBASHIN-4
UBASH3B inhibitor
|
UBASHIN-4 is a small-molecule inhibitor targeting UBASH3B 2HP domain, disrupts mitotic localization of UBASH3B and Aurora B, seletively induces arrest and cell death during mitosis without toxicity to normal cells, selectively suppresses breast and colon tumor growth in vivo. |
| PC-24004 |
AAPK-25
DLGAP5 inhibitor
|
AAPK-25 is a small molecule inhibitor of DLGAP5 with a binding energy of −9.2 Kcal/mol, suppresses proliferation of PRAD cells via inhibiting DLGAP5/E2F1 axis, also is a potent, dual Aurora/PLK coinhibitor. |
| PC-22957 |
CAM2602
Aurora A-TPX2 inhibitor
|
CAM2602 is a potent, selective small molecule inhibitor of Aurora A-TPX2 protein-protein interaction (PPI), binds to Aurora A and displaces TPX2 from Aurora A with a KD of 19 nM, |
| PC-22868 |
MK-8745
Aurora A inhibitor
|
MK-8745 (MK8745) is a potent, specific Aurora kinase A (Aurora A, AURKA) inhibitor with IC50 of 0.6 nM, induces apoptotic cell death in a p53-dependent manner. |
| PC-22152 |
JAB-2485
Aurora A inhibitor
|
JAB-2485 is a potent, highly selective small-molecule Aurora kinase A (AURKA) inhibitor with IC50 of 0.33 nM, with >1500-fold selectivity over AURKB and AURKC. |
| PC-22141 |
DBPR728
Aurora A inhibitor
|
DBPR728 is an oral bioavailable acyl-based prodrug of 6K465, which is a potent selective Aurora A (AURKA) inhibitor, effectively inhibits cancer cells overexpressing c-MYC- and/or N-MYC. |
| PC-22139 |
6K465
Aurora A inhibitor
|
6K465 is a potent selective Aurora A (AURKA) inhibitor, effectively inhibits cancer cells overexpressing c-MYC- and/or N-MYC. |
| PC-21560 |
Reversine
Aurora Kinase inhibitor
|
Reversine is a potent, ATP-competitive Aurora kinases inhibitor with IC50 of 400, 500 and 400 nM for Aurora A, Aurora B and Aurora C, respectively. |
| PC-21147 |
Ilorasertib
Aurora Kinase inhibitor
|
Ilorasertib (ABT-348) is a potent inhibitor of Aurora kinases as well as the VEGF and PDGF families of receptor tyrosine kinases (Aur B IC50=2 nM, PDGFRβ IC50=3 nM). |
| PC-20713 |
LXY18
AURKB inhibitor
|
LXY18 is a potent orally available blocker of AURKB relocation in mitosis with minimum effective concentration (MEC) of 3.5 nM for inducing polyploidy, shows broad-spectrum growth inhibitory and apoptosis-inducing activities with low nanomolar potencies. |
| PC-49273 |
PF-03814735
Aurora inhibitor
|
PF-03814735 is a potent, orally bioavailable, reversible inhibitor of both Aurora A and Aurora B kinases with IC50 values of 0.8 and 5 nM, respectively. |
