Cat. No. |
Product Name |
Information |
PC-38409 |
Miclxin
MIC60 inhibitor
|
Miclxin (DS37262926) is a small molecule inhibitor of MICOS component MIC60, induces mitochondrial stress response in a mutant β-catenin-dependent manner in β-catenin-mutated HCT116 cells, directly binds to mitochondrial inner membrane complex protein MIC60 (SPR Kd=11.9 uM). |
PC-73231 |
GB1874
Beta-catenin-TCF4 inhibitor
|
GB1874 is an inhibitor of the Wnt pathway that targets the β-catenin-TCF4 interaction. |
PC-73060 |
RX-5902
P-p68 inhibitor
|
RX-5902 (Supinoxin, RX5902) is a small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68) and attenuates nuclear shuttling of β-catenin. |
PC-72708 |
ZW4864
BCL9/β-catenin inhibitor
|
ZW4864 (ZW-4864) is an orally bioavailable small-molecule that binds with β-catenin and selectively disrupts the PPI between BCL9 and β-catenin, while sparing the β-catenin/E-cadherin PPI. |
PC-35350 |
SKL2001
Axin/β-catenin inhibitor
|
SKL2001 is a specific small molecule activator (agonist) of the Wnt/β-catenin pathway, stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction. |
PC-35329 |
E-7386
beta-catenin inhibitor
|
E-7386 (E7386) is a potent, orally active modulator of CBP/beta-catenin, disrupts the interaction and inhibits canonical Wnt signaling pathway /TCF reporter gene activity in LiCl-stimulated HEK-293 and MDA-MB-231 with IC50 of 55 and 73 nM, respectively. |
PC-62168 |
CCT-031374
beta-catenin inhibitor
|
CCT-031374 (CCT031374) is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM. |
PC-62166 |
iCRT3
β-catenin responsive transcription inhibitor
|
iCRT-3 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 8.2 nM. |
PC-62165 |
iCRT5
β-catenin responsive transcription inhibitor
|
iCRT5 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 18 nM. |
PC-61811 |
BC-21
β-catenin/TCF4 inhibitor
|
BC-21 (NSC 109268) is a novel small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 6.55 uM. |
PC-61810 |
ZTM000990
β-catenin/TCF4 inhibitor
|
ZTM000990 is a small-molecule antagonist of the oncogenic Tcf4/β-catenin protein complex with IC50 of 0.64 uM. |
PC-61809 |
CWP-232228
β-catenin/TCF4 inhibitor
|
CWP-232228 is a highly potent small-molecule Wnt/β-catenin signaling inhibitor that targets the β-catenin/Tcf4 interaction in the nucleus. |