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Cat. No. Product Name Information
PC-38409

Miclxin

MIC60 inhibitor

Miclxin (DS37262926) is a small molecule inhibitor of MICOS component MIC60, induces mitochondrial stress response in a mutant β-catenin-dependent manner in β-catenin-mutated HCT116 cells, directly binds to mitochondrial inner membrane complex protein MIC60 (SPR Kd=11.9 uM).
PC-73231

GB1874

Beta-catenin-TCF4 inhibitor

GB1874 is an inhibitor of the Wnt pathway that targets the β-catenin-TCF4 interaction.
PC-73060

RX-5902

P-p68 inhibitor

RX-5902 (Supinoxin, RX5902) is a small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68) and attenuates nuclear shuttling of β-catenin.
PC-72708

ZW4864

BCL9/β-catenin inhibitor

ZW4864 (ZW-4864) is an orally bioavailable small-molecule that binds with β-catenin and selectively disrupts the PPI between BCL9 and β-catenin, while sparing the β-catenin/E-cadherin PPI.
PC-35350

SKL2001

Axin/β-catenin inhibitor

SKL2001 is a specific small molecule activator (agonist) of the Wnt/β-catenin pathway, stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction.
PC-35329

E-7386

beta-catenin inhibitor

E-7386 (E7386) is a potent, orally active modulator of CBP/beta-catenin, disrupts the interaction and inhibits canonical Wnt signaling pathway /TCF reporter gene activity in LiCl-stimulated HEK-293 and MDA-MB-231 with IC50 of 55 and 73 nM, respectively.
PC-62168

CCT-031374

beta-catenin inhibitor

CCT-031374 (CCT031374) is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM.
PC-62166

iCRT3

β-catenin responsive transcription inhibitor

iCRT-3 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 8.2 nM.
PC-62165

iCRT5

β-catenin responsive transcription inhibitor

iCRT5 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 18 nM.
PC-61811

BC-21

β-catenin/TCF4 inhibitor

BC-21 (NSC 109268) is a novel small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 6.55 uM.
PC-61810

ZTM000990

β-catenin/TCF4 inhibitor

ZTM000990 is a small-molecule antagonist of the oncogenic Tcf4/β-catenin protein complex with IC50 of 0.64 uM.
PC-61809

CWP-232228

β-catenin/TCF4 inhibitor

CWP-232228 is a highly potent small-molecule Wnt/β-catenin signaling inhibitor that targets the β-catenin/Tcf4 interaction in the nucleus.

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