| Cat. No. |
Product Name |
Information |
| PC-61801 |
UU-T03
β-catenin/TCF4 inhibitor
|
UU-T03 is the ethyl ester derivative of UU-T02, which is a potent, selective inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM. |
| PC-61800 |
UU-T02
β-catenin/TCF4 inhibitor
|
UU-T02 is a novel potent, selective small-molecule inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM. |
| PC-61799 |
UU-T01
β-catenin/TCF4 inhibitor
|
UU-T01 is a novel small-molecule inhibitor of β-catenin/Tcf4 protein-protein interaction with Ki of 3.14 uM, binds to β-catenin with Kd of 0.531 uM.. |
| PC-61798 |
NC-043
β-catenin/TCF4 inhibitor
|
NC-043 (15-Oxospiramilactone) is a diterpenoid derivative inhibitor of Wnt/β-catenin signaling that interferes with the β-catenin/TCF4 association. |
| PC-61786 |
PKF118-310
β-catenin/Tcf4 inhibitor
|
Toxoflavin (PKF118-310) is a novel small molecule inhibitor of Wnt/beta-catenin signaling that selectively disrupts β-catenin/Tcf4 interaction and inhibits its transcriptional activity. |
| PC-61323 |
Carnosic acid
BCL9/β-catenin inhibitor
|
Carnosic acid (Carnosate) is a naturally occurring phenolic compound with antioxidant, anti-inflammatory and antimicrobial properties, inhibits the BCL9/β-catenin interaction with Ki of 3.3 uM. |
| PC-61322 |
CGP049090
β-catenin/LEF1 inhibitor
|
CGP049090 (Cercosporin) is a small-molecule that specifically inhibits the interaction of β-catenin/LEF1 transcriptional complex in colon carcinoma cell lines. |
| PC-61321 |
CCT-031374 hydrobromide
beta-catenin inhibitor
|
A novel small-molecule Wnt signaling inhibitor that inhibits TCF-dependent transcription with IC50 of 6.1 uM in 7dF3 reporter assay. |
| PC-61288 |
Tegatrabetan
beta-catenin inhibitor
|
Tegatrabetan (BC-2059, BC2059, Tegavivint) is an orally bioavailable β-catenin antagonist that disrupts the binding of β-catenin to TBL1 and promotes β-catenin degradation, attenuates nuclear and cytoplasmic levels of β-catenin. |
| PC-70120 |
PRI-724
CBP/beta-catenin inhibitor
|
PRI-724 (Foscenvivint, OP-724) is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM. |
| PC-70092 |
KYA1797K
Wnt/β-catenin inhibitor
|
KYA1797K is a derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling. |
| PC-70091 |
KY-1220
Wnt/β-catenin inhibitor
|
KY-1220 is a small molecule destabilizer of both β-catenin and Ras via inhibition of the Wnt/β-catenin pathway (IC50=2.1 uM). |
