| Cat. No. |
Product Name |
Information |
| PC-28008 |
Caspase-1 inhibitor 6e
Caspase-1 inhibitor
|
Caspase-1 inhibitor 6e is a potent potent, selective Caspase-1 (Interleukin-converting enzyme, ICE) inhibitor with IC50 of 380 nM. |
| PC-28007 |
Ac-LETD-CHO
Caspase-8 inhibitor
|
Ac-LETD-CHO is a specific caspase-8 inhibitor with IC50 of 6.71 nM. |
| PC-28005 |
Ac-DMQD-CHO
Caspase-3 inhibitor
|
Ac-DMQD-CHO (Ac-Asp-Met-Gln-Asp-CHO) is a potent, specific Caspase-3 inhibitor with IC50 of 39 nM. |
| PC-28004 |
Ac-Ile-Glu-Thr-Asp-CHO
Caspase-8 inhibitor
|
Ac-IETD-CHO (Ac-Ile-Glu-Thr-Asp-CHO) is a potent, specific Caspases-8 inhibitor, inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failur, also inhibits cytotoxic T lymphocytes induced cell death. |
| PC-28002 |
VRT-043198
Caspase-1 inhibitor
|
VRT-043198 is the active metabolite of Belnacasan (VX-765), which is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1, exhibits Ki of 0.8 nM and 0.6 nM for ICE/Caspase-1 and Caspase-4, respectively. |
| PC-27891 |
KGR-53P
Caspase-11 inhibitor
|
KGR-53P (Ac-Tle-hGlu(tBu)-hCha-Asp-AOMK) is a peptidic inhibitor of Caspase-11, inhibits LPS-induced pyroptosis in BMDMs with IC50 of 4 uM, inhibits caspase-11-dependent pyroptosis. |
| PC-27890 |
Tetrapeptide KGR-3
Caspase-1/Caspase-4 inhibitor
|
Tetrapeptide KGR-3 (Ac-WEHD-AOMK) is potent and somewhat selective inhibitor of caspase-1 and caspase-4, inhibits caspase-1- or caspase-4-driven pyroptosis and IL-1β secretion. |
| PC-27874 |
Ac-LESD-AMC
Caspase-8 substrate
|
Ac-LESD-AMC is a caspase-8 fluorogenic substrate (relative Kcat/K M = 0.15) that most efficiently hydrolyzed by caspase-8 and caspase-10, 10-fold faster than inflammatory caspases-1, -4, and -5. |
| PC-27754 |
Saikosaponin C
Caspase-3 inhibitor
|
Saikosaponin C is a natural compound purified from the traditional Chinese herb of Radix Bupleuri, exhibits anti-HBV replication activity and inhibits by targeting HNF1α and HNF4αHBV pgRNA synthesis, significantly inhibits LPS-induced apoptotic cell death in HUVECs via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation. |
| PC-26675 |
Ac-DEVD-CHO
Caspase-3 inhibitor
|
Ac-DEVD-CHO is a specific inhibitor of apoptosis and reversible caspase-3 inhibitor with Ki of 0.23 nM. |
| PC-26489 |
Ac-YVAD-CHO
Caspase-1 inhibitor
|
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-1β converting enzyme (ICE, Caspase-1) inhibitor with Ki values of 3.0 and 0.76 nM mouse and human caspase-1, suppresses the production of mature IL-lβ. |
| PC-25677 |
cFLIP inhibitor OH14
cFLIP inhibitor
|
cFLIP inhibitor OH14 is a small-molecule cFLIP-DED1 inhibitor, promotes TRAIL sensitivity via cFLIP, selectively inhibits cFLIP binding to the DISC and promotes TRAIL-mediated apoptosis in breast cancer cell lines. |
