| Cat. No. |
Product Name |
Information |
| PC-43410 |
BOC-D-FMK
Caspase inhibitor
|
BOC-D-FMK is a cell-permeable, irreversible, broad spectrum caspase inhibitor, inhibits apoptosis stimulated by TNF-α with IC50 of 39 uM. |
| PC-43391 |
VX-765
Caspase-1 inhibitor
|
VX-765 (Belnacasan) is an orally absorbed prodrug of VRT-043198, which is a potent and selective inhibitor of interleukin-converting enzyme/caspase-1 with Ki of 0.8 nM. |
| PC-43046 |
Z-DEVD-FMK
Caspase-3 inhibitor
|
Z-DEVD-FMK is a specific caspase-3 inhibitor with IC50 of 18 uM, inhibits apoptosis. |
| PC-42968 |
Q-VD-Oph
pan-Caspase inhibitor
|
Q-VD-Oph (QVD-OPH) is a potent pan-caspase inhibitor, inhibits human recombinant caspase-7 with IC50 of 48 nM in cell-free assay, also inhibits caspase -1, 3, 8, 9, 10, and 12 with IC50 of 25-400 nM. |
| PC-62433 |
Emricasan
Caspase inhibitor
|
Emricasan (IDN-6556, PF-03491390) is a potent, irreversible pan-caspase inhibitor, shows neuroprotective activity for hNPCs, inhibits ZIKV-induced increased caspase-3 activity. |
| PC-62211 |
WF-210
Procaspases-3 activator
|
WF-210 is a PAC-1 derivative and potent activator of procaspases-3 with EC50 of 0.95 uM, displays more cytotoxic than PAC‐1 to human cancer cells, but less cytotoxic to normal cells. |
| PC-62210 |
Procaspase-3 activator 1541B
Procaspases-3 activator
|
Procaspase-3 activator 1541B is a specific, small molecule activator of procaspases-3 with EC50 of 1.3 uM. |
| PC-62209 |
Procaspase-3 activator 1541
Procaspase-3/6 activator
|
Procaspase-3 activator 1541 is a small-molecule inducer of cell death that noncovalently self-assembles into chemical fibrils and activates procaspase-3 and 6 in vitro (EC50=2.4 and 2.8 uM). |
| PC-61354 |
IDN-7314
pan-Caspase inhibitor
|
IDN-7314 is a potent, orally active, and irreversible pan-Caspase protease inhibitor with IC50 of <0.08 to 7 nM for inhibition of activated caspase 3, 6 and 8. |
| PC-70208 |
NWL-117
Caspase-6 inhibitor
|
NWL-117 is a potent, BBB penetrant Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM. |
| PC-60171 |
KEA1-97
Thioredoxin-Caspase 3 inhibitor
|
KEA1-97 (KEA 1-97) is a small molecule that disrupts the interaction of thioredoxin with caspase 3. |
| PC-25488 |
Z-DQMD-FMK
Caspase-3 inhibitor
|
Z-DQMD-FMK is a specific inhibitor of caspase-3, inhibits MG132-induced small cell lung cancer cell death in vitro. |
