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Cat. No. Product Name Information
PC-24248

z-IETD-FMK

Caspase-8 inhibitor

Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor with IC50 of 350 nM.
PC-24054

ORF9b homodimerization inhibitor Y600

ORF9b inhibitor

ORF9b homodimerization inhibitor Y600 is a small molecule inhibitor of ORF9b homodimerization, inhibits ORF9b-ORF9b homotypic interaction, inhibits activation of caspase-1 in A549.ORF9b and THP-1.ORF9b cells with IC50 of 1 and 4 nM respectively.
PC-24053

ORF9b homodimerization inhibitor EN300

ORF9b inhibitor

ORF9b homodimerization inhibitor EN300 is a small molecule inhibitor of ORF9b homodimerization, inhibits ORF9b-ORF9b homotypic interaction, inhibits activation of caspase-1 in A549.ORF9b and THP-1.ORF9b cells with IC50 of 0.85 and 17 nM respectively.
PC-23805

FLIPinBγ

c-FLIPL inhibitor

FLIPinBγ is a first-in class, specific small molecule inhibitor of c-FLIPL in the caspase-8/c-FLIPL heterodimer, promotes CD95L- and TRAIL-mediated loss of cell viability and cell death.
PC-23804

FLIPinB

c-FLIPL inhibitor

FLIPinB is a first-in class, specific small molecule inhibitor of c-FLIPL in the caspase-8/c-FLIPL heterodimer, promotes CD95L- and TRAIL-mediated loss of cell viability and cell death.
PC-22972

Pralnacasan

Caspase-1 inhibitor

Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active caspase 1 (interleukin-1β converting enzyme, ICE) inhibitor with Ki of 1.4 nM, inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ.
PC-22751

Z-YVAD-FMK

Caspase-1 inhibitor

Z-YVAD-FMK is a specific, cell-permeable and irreversible caspase-1 inhibitor with anti-inflammatory and anti-tumor activities. 
PC-22740

Procaspase-3 activator PAC‐1

Procaspase-3 activator

PAC-1 is a small-molecule activator of procaspase-3 to caspase-3, induces apoptosis in cancerous cells, induces apoptosis in HL-60 cells with EC50 of 2.08 uM.
PC-22034

CZL80

Caspase-1 inhibitor

Caspase-1 inhibitor CZL80 is a potent, selective, brain‐penetrable Caspase-1 inhibitor with IC50 of 0.01 uM.

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