| Cat. No. |
Product Name |
Information |
| PC-38397 |
Iclepertin
GlyT1 inhibitor
|
Iclepertin (BI 425809) is a potent, selective and oral glycine transporter 1 (GlyT1) inhibitor with IC50 of 5.2 nM in rat primary neurons and 5.0 nM in human SK‐N‐MC cells (3H‐glycine uptake). |
| PC-35393 |
GlyT1 inhibitor 46
GlyT1 inhibitor
|
GlyT1 inhibitor 46 is a novel potent, selective, orally available inhibitor of glycine transporter-1 (GlyT1) with IC50 of 38 and 21 nM for rat and human GlyT1, respectively. |
| PC-62960 |
ALX-5407 hydrochloride
GlyT1 inhibitor
|
ALX-5407 hydrochloride is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM. |
| PC-61835 |
PF-03463275
GlyT1 inhibitor
|
PF-03463275 (PF 3463275) ia an orally bioavailable, centrally penetrant, potent, reversible, selective, and competitive inhibitor of the human GlyT1 transporter with Ki of 13 nM. |
| PC-61461 |
ALX5407
GlyT1 inhibitor
|
ALX 5407 ((+)-NFPS) is a potent, selective GlyT1 inhibitor that demonstrates >10-fold greater activity in in vitro functional glycine reuptake assay than racemic (±)-NFPS. |
| PC-61460 |
NFPS
GlyT1 inhibitor
|
NFPS (ALX-5407) is a potent, selective GlyT1 inhibitor with IC50 of 2.8 and 9.8 nM for hGlyT1 and rGlyT1 respectively, >5,000-fold selectivity over rGlyT2. |
| PC-61459 |
TASP0315003
GlyT1 inhibitor
|
A potent, selective, orally available GlyT1 inhibitor with IC50 of 1.6 nM, weakly inhibits rat GlyT2 (IC50=138 nM). |
| PC-61458 |
PF-0346275
GlyT1 inhibitor
|
PF-0346275 is a potent, selective, orally available GlyT1 inhibitor with Ki of 11.6 nM, without activity against GlyT2 (IC50>10 uM). |
| PC-61457 |
DCCCyB
GlyT1 inhibitor
|
DCCCyB is a potent, selective, orally available GlyT1 inhibitor with IC50 of 29 nM, demonstrates excellent in vivo occupancy of GlyT1 transporters in vivo. |
| PC-61002 |
ASP2535
GlyT1 inhibitor
|
A potent, selective, brain permeable, orally available glycine transporter-1 (GlyT1) inhibitor with IC50 of 92 nM (rat GlyT1), 50-fold selectivity over GlyT2. |
| PC-60977 |
AMG747
GlyT1 inhibitor
|
AMG747 (Tilapertin) is a nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia. |
| PC-60676 |
GSK494581A
GlyT1 inhibitor
|
GSK 494581A is a potent, specific and mixed glycine transporter subtype 1 (GlyT1) inhibitor (pIC50=7.7) and GPR55 agonist (pEC50=6.5). |
