| Cat. No. |
Product Name |
Information |
| PC-44039 |
NVP-BSK805
JAK2 inhibitor
|
NVP-BSK805 is a potent, selective and ATP-competitive inhibitor of JAK2 (V617F) and wt JAK2 (IC50=0.5 nM). |
| PC-45575 |
CHZ-868
JAK2 inhibitor
|
CHZ-868 (CHZ868) is a potent type II JAK2 inhibitor, inhibits the proliferation of SET2 JAK2 V617F cells (GI50=59 nM). |
| PC-45448 |
Filgotinib
JAK1/2 inhibitor
|
Filgotinib (GLPG 0634) is a potent JAK1/JAK2 inhibitor with IC50 of 10 nM/28 nM in biochemical assays, less potent for JAK3 and TYK2. |
| PC-44289 |
BMS-911543
JAK2 inhibitor
|
BMS-911543 is a potent and selective small-molecule inhibitor of JAK2 with IC50 of 1.1 nM. |
| PC-42751 |
CYT387
JAK1/2 inhibitor
|
Momelotinib (CYT387) is a potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM. |
| PC-45123 |
Itacitinib
JAK1 inhibitor
|
Itacitinib (INCB-039110) is a potent and selective, orally bioactive JAK1 inhibitor with IC50 of 2 nM, shows >20 fold and >200 fold selectivity over JAK2 and JAK3 respectively. |
| PC-22718 |
Coumermycin A1
JAK2 agonist
|
Coumermycin A1 (C-A1) is a small molecule JAK2 agonist that induces dimerization and activation of JAK2, also inhibits DNA Gyrase and cell division in bacteria. |
| PC-22634 |
CS12192
JAK//TBK1 inhibitor
|
CS12192 is a potent, selective JAK3/JAK1/TBK1 inhibitor with IC50 of 11/105/162 nM, respectively. |
| PC-22618 |
Oclacitinib maleate
JAK inhibitor
|
Oclacitinib (PF-03394197) maleate is a potent JAK inhibitor with IC50 of 10, 18, 99, and 84 nM for JAK1, JAK2, JAK3, and TYK2, respectively. |
| PC-22617 |
Oclacitinib
JAK inhibitor
|
Oclacitinib (PF-03394197) is a potent JAK inhibitor with IC50 of 10, 18, 99, and 84 nM for JAK1, JAK2, JAK3, and TYK2, respectively. |
| PC-22495 |
MS-1020
JAK3 inhibitor
|
MS-1020 is a selective, ATP-competitive small molecule JAK3 inhibitor, directly blocks JAK3 catalytic activity, potently inhibits persistently-active STAT3 in a cell type-specific manner. |
| PC-22404 |
GLPG3667
TYK2 inhibitor
|
GLPG3667 is a potent, reversible and selective, ATP-competitive TYK2 inhibitor with IC50 of 2.3 nM. |
