| Cat. No. |
Product Name |
Information |
| PC-61264 |
NC1153
JAK3 inhibitor
|
NC1153 is a Mannich base compound, selective and orally active JAK3 inhibitor that blocks IL-2-induced activation of JAK3 and downstream substrates STAT5a/b. |
| PC-61263 |
EP009
JAK3 inhibitor
|
EP009 is a selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM. |
| PC-60988 |
AS 2553627
JAK inhibitor
|
AS 2553627 (AS2553627) is a novel potent, selective pan-JAK inhibitor with IC50 of 0.46, 0.30, 0.14 and 2.0 nM for JAK1, JAK2, JAK3 and TYK2, respectively. |
| PC-60874 |
Gingerenone A
JAK2/S6K1 inhibitor
|
Gingerenone A is a dual inhibitor of JAK2 and S6K1 pathways, selectively kills cancer cells while exhibiting minimal toxicity toward normal cells. |
| PC-60690 |
JAK3-IN-2
JAK3 inhibitor
|
JAK3-IN-2 is a potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM. |
| PC-60671 |
PF-04965842
JAK1 inhibitor
|
PF-04965842 (Abrocitinib, PF04965842) is a potent, selective, orally bioavailable JAK1 inhibitor with IC50 of 29 nM. |
| PC-60508 |
Delgocitinib
JAK inhibitor
|
Delgocitinib (JTE-052, LEO 124249) is a potent, selective, orally active, pan-JAK inhibitor with IC50 of 2.8, 2.6, 13 and 58 nM for JAK1,2,3 and Tyk2, respectively. |
| PC-60314 |
PF-956980
JAK3 inhibitor
|
PF-956980 is a potent, highly specific JAK3 inhibitor with IC50 of 4 nM. |
| PC-60312 |
PF-06263276
pan-JAK inhibitor
|
PF-06263276 (PF06263276, PF 6263276) is a potent, selective pan JAK inhibitor with IC50 of 2.2, 23.1, 59.9 and 29.7 nM for JAK1, JAK2, JAK3, and TYK2, respectively. |
| PC-45653 |
Upadacitinib
JAK1 inhibitor
|
Upadacitinib (ABT-494) is a potent and selective JAK1 inhibitor with celluar IC50 of 8 nM, biochemical IC50 of 40 nM. |
| PC-45652 |
Peficitinib
JAK inhibitor
|
Peficitinib (ASP-015K, JNJ-54781532) is a potent JAK inhibitor with IC50s of 3.9 and 0.7 nM for JAK1 and JAK3 respectively. |
| PC-45664 |
NS-018 hydrochloride
JAK2 inhibitor
|
NS-018 hydrochloride (NS018, Ilginatinib) is a potent and highly selective JAK2 inhibitor (IC50=0.72 nM). |
