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Cat. No. Product Name Information
PC-62971

WYE-151650

JAK3 inhibitor

WYE-151650 is a potent, selective JAK3 inhibitor with IC50 of 0.8 nM, displays 36-, 14-, and 34-fold selectivity against JAK-1, JAK-2, and Tyk-2, respectively.
PC-62841

JAK-IN-35

JAK1/JAK3 inhibitor

JAK-IN-35 is a potent and efficacious dual JAK1/JAK3 inhibitor with IC50 of 0.9/1.9 nM.
PC-62557

PRN371

JAK3 inhibitor

PRN371 is a novel potent, selective JAK3 inhibitor with IC50 of 0.5 nM, displays >250-fold selectivity over JAK1, JAK2, and TYK2.
PC-62334

PF-06651600 malonate

JAK3 inhibitor

PF-06651600 malonate (Ritlecitinib) is a novel potent, selective JAK3 inhibitor with IC50 of 0.346 nM, displays >1,000-fold selectivity over JAK1 and JAK2.
PC-62333

PF-06651600

JAK3 inhibitor

Ritlecitinib (PF-06651600) is a novel potent, selective JAK3 inhibitor with IC50 of 0.346 nM, displays >1,000-fold selectivity over JAK1 and JAK2.
PC-62263

JAK3i

JAK3 inhibitor

JAK3i is a potent, selective, covalent JAK3 kinase inhibitor with IC50 of 0.43 nM, shows high selectivity (>3,000-fold) against the closely related kinase domains in JAK1, JAK2, or TYK2.
PC-62261

JKA3 inhibitor 31

JAK3 inhibitor

JKA3 inhibitor 31 is a highly potent, selective, reversible, covalent JAK3 inhibitor with IC50 of 49 nM, shows no activity against other JAK kinases.
PC-61986

AZD 4205

JAK1 inhibitor

Golidocitinib (AZD4205) is a potent, selective JAK1 inhibitor IC50 of 73 nM and Ki of 2.8 nM, shows high selectivity against JAK2 and JAK3 with IC50 of 13,233 nM and >30,000 nM respectively.
PC-61819

PF-06700841

Dual JAK1/TYK2 inhibitor

PF-06700841 (Brepocitinib, PF 06700841) is a potent dual JAK1/TYK2 inhibitor with IC50 of 17/23 nM, inhibits JAK2 and JAK3 with IC50=77 and 6494 nM, respectively.
PC-61818

PF-06700841 tosylate

JAK1/TYK2 inhibitor

PF-06700841 tosylate (Brepocitinib, PF 06700841) is a potent dual JAK1/TYK2 inhibitor with IC50 of 17/23 nM, inhibits JAK2 and JAK3 with IC50=77 and 6494 nM, respectively.
PC-61264

NC1153

JAK3 inhibitor

NC1153 is a Mannich base compound, selective and orally active JAK3 inhibitor that blocks IL-2-induced activation of JAK3 and downstream substrates STAT5a/b.
PC-61263

EP009

JAK3 inhibitor

EP009 is a selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM.

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