Cat. No. |
Product Name |
Information |
PC-21596 |
JNJ-64251330
JAK inhibitor
|
Lorpucitinib (JNJ-64251330) is potent, selective and orally bioavailable pan-JAK inhibitor with IC50 of 0.37/8.6/92/7.4 nM for JAK1/JAK2/JAK3/Tyk2 respectively. |
PC-21425 |
WHI-P131
JAK3 inhibitor
|
WHI-P131 (JANEX-1) is a potent and selective JAK3 inhibitor with Ki of 2.3 uM and IC50 of 78 uM, with no activity agianst JAK1 and JAK2. |
PC-21376 |
MMT3-72
JAK inhibitor
|
MMT3-72 is a gastrointestinal locally-activating Janus kinase (JAK) inhibitor, readily converted to MMT3-72-M2 in the colon contents (JAK1 IC50=10.8 nM, JAK2 IC50=26.3 nM and TYK2 IC50=91.6 nM). |
PC-21281 |
QL-1200186
TYK2-JH2 inhibitor
|
QL-1200186 is a potent, highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 0.06 nM, targets pseudokinase regulatory domain (Janus homology 2, JH2) of the TYK2 protein. |
PC-21215 |
GDC-4379
JAK inhibitor
|
GDC-4379 is a potent, selective and inhaled JAK inhibitor, reduces FeNO and peripheral biomarkers of inflammation. |
PC-20901 |
YLIU-5-162-1
JAK2 inhibitor
|
YLIU-4-105-1 is a novel type II JAK2 inhibitor, binds to JAK2 kinase domain (JH1), show potential for overcoming acquired resistance to ruxolitinib. |
PC-20543 |
ABT-317
JAK1 inhibitor
|
ABT-317 (ABT317) is a potent, selective JAK1 inhibitor, inhibits IL-6-stimulated pSTAT3 (TF-1 cells, IC50=16 nM) and IL-2-stimulated pSTAT5 (T-blasts, IC50=30 nM). |
PC-20060 |
Nimucitinib
JAK inhibitor
|
Nimucitinib is a potent, selective Janus kinase (JAK) inhibitor. |
PC-49397 |
Ifidancitinib
JAK inhibitor
|
Ifidancitinib (ATI-502, ATI-50002, R507) is a potent and selective next-generation JAK1/3 inhibitor, potently inhibits γc cytokine signaling. |
PC-49377 |
JAK-IN-21
JAK inhibitor
|
JAK-IN-21 is a selective and potent JAK inhibitor with IC50 of 1.73, 2.04, 109 and 62.9 nM against JAK1, JAK2, J2V617F and TYK2, respectively. |
PC-73205 |
Cerdulatinib hydrochloride
dual SYK/JAK inhibitor
|
Cerdulatinib (PRT062070) is a potent, ATP-competitive, orally active dual SYK/JAK inhibitor with IC50 of 32 nM (Syk), 0.5-12 nM (JAK1/2/3, Tyk2). |
PC-73204 |
Cerdulatinib
dual SYK/JAK inhibitor
|
Cerdulatinib (PRT062070) is a potent, ATP-competitive, orally active dual SYK/JAK inhibitor with IC50 of 32 nM (Syk), 0.5-12 nM (JAK1/2/3, Tyk2). |