JAK compound (inhibitors, antagonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-20543	ABT-317 JAK1 inhibitor	ABT-317 (ABT317) is a potent, selective JAK1 inhibitor, inhibits IL-6-stimulated pSTAT3 (TF-1 cells, IC50=16 nM) and IL-2-stimulated pSTAT5 (T-blasts, IC50=30 nM).
PC-72038	NDI-031407 TYK2 inhibitor	NDI-031407 (NDI 031407) is a novel potent, selective TYK2 inhibitor with IC50 of 0.21 nM in radiometric assays, 20 fold selectivity over JAK3 (4.2 nM), 147 fold for JAK2 (31 nM), and 220 fold for JAK1 (46 nM).
PC-61277	EXEL-8232	A potent and selective, orally bioavailable JAK2 inhibitor with IC50 of 2 nM.
PC-45817	Tofacitinib citrate	A potent, specific, orally active inhibitor of JAK3 with IC50 of 1 nM in cell-free assays.

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