| Cat. No. |
Product Name |
Information |
| PC-49343 |
VVD-118313
JAK1 inhibitor
|
VVD-118313 (VVD118313) is a potent, selective and allosteric inhibitor of the non-catalytic pseudokinase domain of JAK1 (C817), blocks JAK1-dependent trans-phosphorylation and cytokine signaling. |
| PC-49307 |
AZD0449
JAK1 inhibitor
|
AZD0449 (AZD-0449) is a potent and highly selective JAK1 inhibitor with IC50 of 2.4 nM, displays >50-fold selectivity over TYK2 and JAK2, and no inhibition against JAK3. |
| PC-49274 |
Z583
JAK3 inhibitor
|
Z583 is a potent, highly selective JAK3 inhibitor with IC50 of 0.1 nM, 4500-fold selectivity over other JAK subtypes. |
| PC-49112 |
TYK2-JH1 inhibitor 30
TYK2-JH1 inhibitor
|
TYK2-JH1 inhibitor 30 is a potent and selective TYK2-JH1 inhibitor with Ki of 0.51 nM. |
| PC-38399 |
Ilunocitinib
JAK inhibitor
|
Ilunocitinib (LY-3411067) is a potent, small molecule JAK inhibitor. |
| PC-38381 |
Nezulcitinib
pan JAK inhibitor
|
Nezulcitinib (TD-0903) is a inhaled lung-selective pan-JAK inhibitor, targets all JAK isoforms (JAK1, JAK2, JAK3, TYK2), Nezulcitinib is under development for treatment of acute lung injury associated with COVID-19. |
| PC-73438 |
Povorcitinib
JAK1 inhibitor
|
Povorcitinib (INCB054707) is a potent, selective and oral JAK1 inhibitor with IC50 of 8.9 nM, 52-fold selective over JAK2 (IC50=463 nM). |
| PC-73423 |
Ivarmacitinib
JAK1 inhibitor
|
Ivarmacitinib (SHR0302) is a potent highly selective, Janus kinase 1 (JAK1) inhibitor with IC50 of 0.1 nM, 9-fold selectivity over JAK2 and >70-fold over JAK3 and TYK2. |
| PC-73400 |
Atinvicitinib
JAK inhibitor
|
Atinvicitinib is a pyrazole compound and JAK inhibitor with IC50 of 0.4, 6 and 13 nM against JAK1, JAK2, and TYK2, less potent for JAK3 (IC50=1130 nM), has the potential for the research of atopic dermatitis. |
| PC-73205 |
Cerdulatinib hydrochloride
dual SYK/JAK inhibitor
|
Cerdulatinib (PRT062070) is a potent, ATP-competitive, orally active dual SYK/JAK inhibitor with IC50 of 32 nM (Syk), 0.5-12 nM (JAK1/2/3, Tyk2). |
| PC-73204 |
Cerdulatinib
Dual SYK/JAK inhibitor
|
Cerdulatinib (PRT062070) is a potent, ATP-competitive, orally active dual SYK/JAK inhibitor with IC50 of 32 nM (Syk), 0.5-12 nM (JAK1/2/3, Tyk2). |
| PC-73190 |
Baricitinib
JAK1/JAK2 inhibitor
|
Baricitinib (LY3009104, INCB028050) is a potent, selective and orally bioavailable JAK1/JAK2 inhibitor with IC50 of 5.9/5.7 nM, respectively. |
