| Cat. No. |
Product Name |
Information |
| PC-73423 |
Ivarmacitinib
JAK1 inhibitor
|
Ivarmacitinib (SHR0302) is a potent highly selective, Janus kinase 1 (JAK1) inhibitor with IC50 of 0.1 nM, 9-fold selectivity over JAK2 and >70-fold over JAK3 and TYK2. |
| PC-73400 |
Atinvicitinib
JAK inhibitor
|
Atinvicitinib is a pyrazole compound and JAK inhibitor with IC50 of 0.4, 6 and 13 nM against JAK1, JAK2, and TYK2, less potent for JAK3 (IC50=1130 nM), has the potential for the research of atopic dermatitis. |
| PC-73064 |
LAS194046
pan-JAK inhibitor
|
LAS194046 (LAS-194046) is a potent, selective pan-JAK inhibitor with IC50 of 5.46/0.4/ 2.07 nM against JAK1/2/3, less potent in TYK2 activity (IC50=21.8 nM). |
| PC-73037 |
Deucravacitinib
TYK2 inhibitor
|
BMS-986165 (Deucravacitinib, BMS986165) is potent, high selective allosteric inhibitor of TYK2 with Ki of 0.02 nM, IC50 of 0.2 nM. |
| PC-72613 |
Ropsacitinib
TYK2 inhibitor
|
Ropsacitinib (PF-06826647) is a potent, selective TYK2 inhibitor with IC50 of 15 nM, inhibits JAK1/2/3 with IC50 of 383/74/>10,000 nM. |
| PC-72603 |
AZD4604
JAK1 inhibitor
|
AZD4604 (AZD-4604) is a, potent, highly selective, ATP-competitive and oral JAK1 inhibitor with IC50 of 0.54 nM, shows >1000-fold selectivity over other JAK family members. |
| PC-72341 |
TD-1473
Pan-JAK inhibitor
|
TD-1473 (Izencitinib, TD1473, JNJ 8398) is a potent, selective, oral gut-selective pan-JAK inhibitor with pKi of 10.0/10.0/8.8/9.5 for human recombinant JAK1, JAK2, JAK3 and TYK2. |
| PC-38210 |
BMS-986202
TYK2 inhibitor
|
BMS-986202 (BMS 986202) is potent, selective Tyk2 inhibitor that binds to Tyk2 JH2 domain with IC50 of 0.19 nM, Ki of 0.02 nM, >10,000-fold over 273 kinases and pseudokinases. |
| PC-38049 |
GDC-046
TYK2 inhibitor
|
GDC-046 is a potent, selective, and orally bioavailable inhibitor of TYK2 with with Kis of 4.8, 0.7, 0.7, and 0.4 nM for TYK2, JAK1, JAK2, and JAK3, respectively. |
| PC-38034 |
FM479
|
FM-479 is an FM-381 structural analog, the negative control of FM-381 and has no activity on JAK3 or other kinases. |
| PC-38006 |
Flonoltinib maleate
JAK2/FLT3 inhibitor
|
Flonoltinib maleate is a potent, highly selective, dual JAK2/FLT3 inhibitor with IC50 of 0.8, 1.4, and 15 nM for JAK2, JAK2V617F, and FLT3, respectively. |
| PC-38005 |
Flonoltinib
JAK2/FLT3 inhibitor
|
Flonoltinib is a potent, highly selective, dual JAK2/FLT3 inhibitor with IC50 of 0.8, 1.4, and 15 nM for JAK2, JAK2V617F, and FLT3, respectively. |
