| Cat. No. |
Product Name |
Information |
| PC-35830 |
iJak-381
JAK1 inhibitor
|
iJak-381 (iJak381) is a potent, selective inhalable and lung-restricted inhibitor of JAK1 with IC50 of 8.52 nM, displays 6.3/704/28 fold selectivity over JAK2/JAK3/TYK2. |
| PC-63575 |
FM-381
|
FM-381 (FM381) is a potent, specific, reversible and covalent inhibitor of JAK3 with IC50 of 127 pM, 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and Tyk2, respectively. |
| PC-43113 |
ZM39923
JAK3 inhibitor
|
ZM39923 is a potent, selective JAK3 inhibitor with pIC50 of 7.1, also potently inhibits human tissue transglutaminase (TGM2, hTG2) with IC50 of 10 nM. |
| PC-62972 |
NIBR-3049
JAK3 inhibitor
|
NIBR-3049 (TCS-21311) is a potent, highly selective JAK3 inhibitor with IC50 of 8 nM, displays >100-fold selectivity over JAK1, JAK2 and TYK2, also inhibits PKCα, PKCθ, and GSK3β with IC50 of 13, 68, and 3 nM, respectively.. |
| PC-62334 |
PF-06651600 malonate
|
PF-06651600 malonate (Ritlecitinib) is a novel potent, selective JAK3 inhibitor with IC50 of 0.346 nM, displays >1,000-fold selectivity over JAK1 and JAK2. |
| PC-62333 |
PF-06651600
|
Ritlecitinib (PF-06651600) is a novel potent, selective JAK3 inhibitor with IC50 of 0.346 nM, displays >1,000-fold selectivity over JAK1 and JAK2. |
| PC-61986 |
AZD 4205
JAK1 inhibitor
|
Golidocitinib (AZD4205) is a potent, selective JAK1 inhibitor IC50 of 73 nM and Ki of 2.8 nM, shows high selectivity against JAK2 and JAK3 with IC50 of 13,233 nM and >30,000 nM respectively. |
| PC-61819 |
PF-06700841
Dual JAK1/TYK2 inhibitor
|
PF-06700841 (Brepocitinib, PF 06700841) is a potent dual JAK1/TYK2 inhibitor with IC50 of 17/23 nM, inhibits JAK2 and JAK3 with IC50=77 and 6494 nM, respectively. |
| PC-60988 |
AS 2553627
|
AS 2553627 (AS2553627) is a novel potent, selective pan-JAK inhibitor with IC50 of 0.46, 0.30, 0.14 and 2.0 nM for JAK1, JAK2, JAK3 and TYK2, respectively. |
| PC-60874 |
Gingerenone A
|
Gingerenone A is a dual inhibitor of JAK2 and S6K1 pathways, selectively kills cancer cells while exhibiting minimal toxicity toward normal cells. |
| PC-60690 |
JAK3-IN-2
|
JAK3-IN-2 is a potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM. |
| PC-60671 |
PF-04965842
JAK1 inhibitor
|
PF-04965842 (Abrocitinib, PF04965842) is a potent, selective, orally bioavailable JAK1 inhibitor with IC50 of 29 nM. |
