| Cat. No. |
Product Name |
Information |
| PC-35830 |
iJak-381
JAK1 inhibitor
|
iJak-381 (iJak381) is a potent, selective inhalable and lung-restricted inhibitor of JAK1 with IC50 of 8.52 nM, displays 6.3/704/28 fold selectivity over JAK2/JAK3/TYK2. |
| PC-35502 |
JAK2 inhibitor G5-7
JAK2 inhibitor
|
JAK2 inhibitor G5-7 is a small molecule, allosteric JAK2 inhibitor that selectively inhibits JAK2-mediated phosphorylation and activation of EGFR and STAT3 by binding to JAK2. |
| PC-63575 |
FM-381
JAK3 inhibitor
|
FM-381 (FM381) is a potent, specific, reversible and covalent inhibitor of JAK3 with IC50 of 127 pM, 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and Tyk2, respectively. |
| PC-43343 |
LY2784544
JAK2 V617F inhibitor, GPR39 agonist
|
LY2784544 (Gandotinib) is a potent, selective and ATP-competitive inhibitor of JAK2 V617F, effectively inhibits JAK2V617F-driven signaling and cell proliferation in Ba/F3 cells (IC50=20 and 55 nM, respectively). |
| PC-63194 |
Atiprimod dihydrochloride
JAK2 inhibitor
|
Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways. |
| PC-63193 |
Atiprimod
JAK2 inhibitor
|
Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways. |
| PC-43113 |
ZM39923
JAK3 inhibitor
|
ZM39923 is a potent, selective JAK3 inhibitor with pIC50 of 7.1, also potently inhibits human tissue transglutaminase (TGM2, hTG2) with IC50 of 10 nM. |
| PC-43112 |
ZM39923 hydrochloride
JAK3 inhibitor
|
ZM39923 is a potent, selective JAK3 inhibitor with pIC50 of 7.1, also potently inhibits human tissue transglutaminase (TGM2) with IC50 of 10 nM. |
| PC-43049 |
Decernotinib
JAK3 inhibitor
|
Decernotinib (VX-509, VRT-831509) is a potent, selective, orally available JAK3 inhibitor with Ki of 2.5 nM and cellular IC50 of 50-170 nM, demonstrates limited inhibition of JAK1/JAK2/TYK2 in cell-based assays (25-100 fold). |
| PC-63072 |
Tyk2-IN-30
Tyk2 inhibitor
|
TYK2-IN-30 is a potent, selective and orally active Tyk2 inhibitor with Ki of 0.7 nM, exhibits excellent selectivity (35-fold for JAK1 and 83-fold for JAK3). |
| PC-63069 |
JAK1-IN-31
JAK1 inhibitor
|
JAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM, less potent for JAK3 (Ki=280 nM) and Tyk2 (Ki=12 nM) and no inhibition on hERG and CYP3A4 (IC50>10 uM). |
| PC-62972 |
NIBR-3049
JAK3 inhibitor
|
NIBR-3049 (TCS-21311) is a potent, highly selective JAK3 inhibitor with IC50 of 8 nM, displays >100-fold selectivity over JAK1, JAK2 and TYK2, also inhibits PKCα, PKCθ, and GSK3β with IC50 of 13, 68, and 3 nM, respectively.. |
