| Cat. No. |
Product Name |
Information |
| PC-63069 |
JAK1-IN-31
JAK1 inhibitor
|
JAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM, less potent for JAK3 (Ki=280 nM) and Tyk2 (Ki=12 nM) and no inhibition on hERG and CYP3A4 (IC50>10 uM). |
| PC-62972 |
NIBR-3049
JAK3 inhibitor
|
NIBR-3049 (TCS-21311) is a potent, highly selective JAK3 inhibitor with IC50 of 8 nM, displays >100-fold selectivity over JAK1, JAK2 and TYK2, also inhibits PKCα, PKCθ, and GSK3β with IC50 of 13, 68, and 3 nM, respectively.. |
| PC-62971 |
WYE-151650
JAK3 inhibitor
|
WYE-151650 is a potent, selective JAK3 inhibitor with IC50 of 0.8 nM, displays 36-, 14-, and 34-fold selectivity against JAK-1, JAK-2, and Tyk-2, respectively. |
| PC-62841 |
JAK-IN-35
JAK1/JAK3 inhibitor
|
JAK-IN-35 is a potent and efficacious dual JAK1/JAK3 inhibitor with IC50 of 0.9/1.9 nM. |
| PC-62557 |
PRN371
JAK3 inhibitor
|
PRN371 is a novel potent, selective JAK3 inhibitor with IC50 of 0.5 nM, displays >250-fold selectivity over JAK1, JAK2, and TYK2. |
| PC-62334 |
PF-06651600 malonate
|
PF-06651600 malonate (Ritlecitinib) is a novel potent, selective JAK3 inhibitor with IC50 of 0.346 nM, displays >1,000-fold selectivity over JAK1 and JAK2. |
| PC-62333 |
PF-06651600
JAK3 inhibitor
|
Ritlecitinib (PF-06651600) is a novel potent, selective JAK3 inhibitor with IC50 of 0.346 nM, displays >1,000-fold selectivity over JAK1 and JAK2. |
| PC-62263 |
JAK3i
JAK3 inhibitor
|
JAK3i is a potent, selective, covalent JAK3 kinase inhibitor with IC50 of 0.43 nM, shows high selectivity (>3,000-fold) against the closely related kinase domains in JAK1, JAK2, or TYK2. |
| PC-62261 |
JKA3 inhibitor 31
JAK3 inhibitor
|
JKA3 inhibitor 31 is a highly potent, selective, reversible, covalent JAK3 inhibitor with IC50 of 49 nM, shows no activity against other JAK kinases. |
| PC-61986 |
AZD 4205
JAK1 inhibitor
|
Golidocitinib (AZD4205) is a potent, selective JAK1 inhibitor IC50 of 73 nM and Ki of 2.8 nM, shows high selectivity against JAK2 and JAK3 with IC50 of 13,233 nM and >30,000 nM respectively. |
| PC-61819 |
PF-06700841
Dual JAK1/TYK2 inhibitor
|
PF-06700841 (Brepocitinib, PF 06700841) is a potent dual JAK1/TYK2 inhibitor with IC50 of 17/23 nM, inhibits JAK2 and JAK3 with IC50=77 and 6494 nM, respectively. |
| PC-61818 |
PF-06700841 tosylate
JAK1/TYK2 inhibitor
|
PF-06700841 tosylate (Brepocitinib, PF 06700841) is a potent dual JAK1/TYK2 inhibitor with IC50 of 17/23 nM, inhibits JAK2 and JAK3 with IC50=77 and 6494 nM, respectively. |
