| Cat. No. |
Product Name |
Information |
| PC-22664 |
JKC-363
MC4R antagonist
|
JKC-363 (JKC363) is a highly potent, selective melanocortin MC4 receptor antagonist with IC50 of 0.5 nM, 90-fold selective over MC3 receptor. |
| PC-21480 |
MCL0020
MC4R inverse agonist
|
MCL0020 is a potent, selective inverse agonist of melanocortin MC4 receptor (MC4R) with binding IC50 of 11.6 nM, shows negligible affinity for MC1 and MC3 receptors. |
| PC-49761 |
SNT-207858
MC4R antagonist
|
SNT-207858 (SNT207858) is a potent, selective, BBB-penetrating, and orally active melanocortin-4 (MC4R) receptor antagonist with binding/fuaction IC50 of 22/11 nM, respectively. |
| PC-49760 |
PF-07258669
MC4R inhibitor
|
PF-07258669 (PF 07258669) is a potent, selective, and orally bioavailable melanocortin-4 receptor (MC4R) antagonist with Ki of 0.46 nM and human MC4R inverse agonist potency (IC50=13 nM). |
| PC-49060 |
TCMCB07
MC4R antagonist
|
TCMCB07 is a synthetic, cyclic nonapeptide peptide antagonist of the melanocortin-4 receptor (MC4R), ameliorates cancer- and chronic kidney disease-associated cachexia. |
| PC-38702 |
CRN04894
MC2R antagonist
|
CRN04894 is a highly potent, selective, orally available melanocortin 2 receptor (MC2R antagonist) antagonist with Ki of 2.1 nM. |
| PC-36115 |
Ro 27-3225
MC4R agonist
|
Ro 27-3225 (Ro27-3225, Ro 27-3225 trifluoroacetate salt) is a potent, selective melanocortin melanocortin receptor MC4R agonist with EC50 of 1 nM, >30-fold selectivity over MC3R. |
| PC-35970 |
JNJ-10229570
MC1R/MC5R antagonist
|
JNJ-10229570 (JNJ10229570) is a novel potent, selective melanocortin receptor MC1R and MC5R antagonist with binding IC50 of 270 nM and 200 nM, respectively. |
| PC-35446 |
Dersimelagon
MC1R agonist
|
Dersimelagon (MT-7117) is an orally bioavailable selective, non-peptide melanocortin-1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human, cynomolgus monkey, mouse and rat MC1R, respectively. |
| PC-61574 |
ML00253764 hydrochloride
MC4R antagonist
|
ML00253764 hydrochloride is a non-peptide, brain penetrant melanocortin MC4 receptor (MC4R) antagonist with IC50 of 0.32, 0.81 and 2.12 uM for MC4, MC3 and MC5 receptors, respectively. |
| PC-61573 |
ML00253764
MC4R antagonist
|
ML00253764 is a non-peptide, brain penetrant melanocortin MC4 receptor (MC4R) antagonist with IC50 of 0.32, 0.81 and 2.12 uM for MC4, MC3 and MC5 receptors, respectively. |
| PC-61572 |
BL-6020 979
MC4R antagonist
|
BL-6020/979 (SNT207979) is an orally available, selective, potent MC4R antagonist with IC50 of 19 nM. |
