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Request The Product List ofSmoothened (Smo) Smoothened (Smo)

Cat. No. Product Name Information
PC-36044

Glasdegib

Smoothened inhibitor

Glasdegib (PF-04449913) is a potent, orally bioavailable smoothened (SMO) inhibitor with IC50 of 5 nM in the Gli-luciferase reporter assays, binds to human SMO (AA181-787) with IC50 of 4 nM.
PC-35986

MU1300

Hedgehog modulator

MU1300 (MU-1300) is novel effective, selective modulator of the Hedgehog (Hh) pathway, suppresses Hh-dependent osteogenesis with IC50 of 300 nM in osteoblast differentiation assay using C3H10T1/2 cells, targets and binds to Smoothened (Smo) directly.
PC-62178

CUR61414

Hh signaling inhibitor

CUR61414 is a small molecule Hedgehog (Hh) inhibitor that can block elevated Hh signaling activity resulting from oncogenic mutations in Patched-1, binds directly with Smoothened (Ki=44 nM).
PC-62171

SANT-1

Smoothened inhibitor

SANT-1 is a potent, cell-permeable Smoothened inhibitor (Kd=1.2 nM) that inhibits Sonic hedgehog (Shh) signaling.
PC-62169

Saridegib

Saridegib (Patidegib, IPI-926) is a potent and orally active Hedgehog (Hh) pathway antagonist with IC50 of 7 nM.
PC-61149

Smoothib

Smoothib is a novel potent inhibitor of hedgehog (Hh) signaling (IC50=157±118 nM) and an antagonist of the protein smoothened (Smo), binds to the heptahelical bundle of Smo with Kd of 59 nM.
PC-42586

Vismodegib

Smoothened inhibitor

Vismodegib (GDC-0449) is a potent, selective, orally bioavailable smoothened (Smo) inhibitor, blocks Shh signaling with EC50 of 40 nM.
PC-20089

MRT-92

Smoothened inhibitor

MRT-92 is a potent selective Smoothened (Smo) receptor antagonist (Kd=0.3 nM), inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation with IC50 of 0.4 nM.
PC-38710

Sonidegib phosphate

Smoothened inhibitor

Sonidegib (Erismodegib, LDE225, NVP-LDE225) is potent, selective, orally available Smoothened (SMO) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively.
PC-38709

Sonidegib

Smoothened inhibitor

Sonidegib (Erismodegib, LDE225, NVP-LDE225) is potent, selective, orally available Smoothened (SMO) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively.
PC-43422

LY2940680

LY2940680 (Taladegib) is potent Smoothened (SMO) receptor antagonist, potently inhibits Hedgehog (Hh) signaling with IC50 of 6.3 nM in Gli-luc reporter assyas.
PC-43256

SAG

SAG is a small molecule Hedgehog (Hh) pathway agonist with EC50 of 3 nM, specifically binds to the Smoothened (Smo) heptahelical bundle (Kd=59 nM).

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