| Cat. No. |
Product Name |
Information |
| PC-20544 |
ABT-418
nAChR activator
|
ABT-418 (ABT418) is an analog of (-)-nicotine and cholinergic ligand (activator) of nAChRs, a potent inhibitor of [3H]-cytisine binding to nAChR in rat brain with Ki of 2 nM. |
| PC-49428 |
AT1001
α3β4 nAChR inhibitor
|
AT1001 (AT-1001) is a high affinity and selective α3β4 nAChR antagonist with Ki value of 2.4 nM, >90-fold selectivity over the other major subtypes (α4β2 and α7 nAChR). |
| PC-38681 |
Simpinicline
nAChR agonist
|
Simpinicline (OC-02) is a highly selective nicotinic acetylcholine receptor (nAChR) agonist, exhibits potent antiviral activity against the SARS-CoV-2 variants in cell culture with IC50 of 40 nM. |
| PC-38475 |
4BP-TQS
α7 nAChR agonist
|
4BP-TQS (GAT107 racemic) is a potent, selective, allosteric agonist of α7 nAChRs with EC50 of 17 uM, no activity for α1β1δε-, α3β4-, and α4β2 subunit-containing nAChRs at 100 uM. |
| PC-72282 |
TC-6683
α4β2 agonist
|
TC-6683 (AZD1446) is a potent and highly selective α4β2 nAChR agonist with Ki of 30/34 nM against hα4β2/rα4β2, with little to no affinity against h α3β2 and h α7 (Ki>6.7 uM). |
| PC-72170 |
AP-202
α4β2 antagonist
|
AP-202 (AP202) is a highly potent and selective α4β2 nAChR antagonist with binding Ki of 18 nM, 57-fold selectivity over α3β4 receptor. |
| PC-35867 |
B-973B
|
B-973 (B973) is a potent, selective α7 nAChR ago-PAM, denonstrates analgesic effect with attenuating pain behavior and decreasing paw edema in vivo.. |
| PC-35624 |
Nelonicline
|
Nelonicline (ABT-126) is a potent, selective α7 nicotinic receptor (nAChR) partial agonist for the treatment of cognitive impairment with schizophrenia.. |
| PC-43406 |
RJR-2403 hemioxalate
|
RJR-2403 (Rivanicline, Metanicotine) is a potent, selective neuronal nicotinic ACh (nAChR) agonist with high affinity to rat brain cortex (Ki=26 nM), does not significantly activate muscle type nAChRs or muscarinic receptors. |
| PC-43405 |
RJR-2403
|
RJR-2403 (Rivanicline, Metanicotine) is a potent, selective neuronal nicotinic ACh (nAChR) agonist with high affinity to rat brain cortex (Ki=26 nM), does not significantly activate muscle type nAChRs or muscarinic receptors. |
| PC-43404 |
RJR-2403 oxalate
|
RJR-2403 (Rivanicline, Metanicotine) is a potent, selective neuronal nicotinic ACh (nAChR) agonist with high affinity to rat brain cortex (Ki=26 nM), does not significantly activate muscle type nAChRs or muscarinic receptors. |
| PC-42900 |
A-867744
|
A-867744 is a potent, selective α7 nAChR positive allosteric modulator (PAM) with Ki of 23 nM, potentiates acetylcholine (ACh)-evoked currents with EC50 of 1 uM. |
