| Cat. No. |
Product Name |
Information |
| PC-23864 |
GTS-21 dihydrochloride
α7 nAChR agonist
|
GTS-21 dihydrochloride (DMXBA) is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist, is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist. |
| PC-23863 |
GTS-21
α7 nAChR agonist
|
GTS-21 (DMXBA) is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist, is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.
GTS-21 (DMXBA) shows anti‑inflammatory and cognition‑enhancing activities. |
| PC-23179 |
SR9883
α4β2* nAChRs enhancer
|
SR9883 is a potent, selective and brain-penetrant enhanceer of α4β2* nAChRs with EC50 of 0.2-0.4 uM, shows no activity against α3β2* or α3β4* nAChRs. |
| PC-22783 |
PHA-543613
α7 nAChR agonist
|
PHA-543613 is a potent, selective agonist of alpha7 neuronal nicotinic acetylcholine receptor (α7 nAChR) with Ki of 8.8 nM, EC50 of 65 nM in cell-based FLIPR assay. |
| PC-22398 |
MB327
61368-98-7
|
MB327 is an antinicotinic bispyridinium compound, restores functional activity of nAChR. MB327 could restore soman-impaired neuromuscular function in vitro and improve survival of sarin, soman and tabun poisoned guinea pigs in vivo. |
| PC-22294 |
GAT2711
α9 nAChR agonist
|
GAT2711 is a potent, selective full agonist of α9 nAChR with EC50 of 230 nM, 340-fold selective over α7 nAChR. |
| PC-21718 |
DM506
nAChR inhibitor
|
DM506 is a novel ibogamine derivative and inhibitor of α7 and α9α10 nicotinic acetylcholine receptors (nAChRs) with IC50 of 5.1 uM, 5.6 uM and 6.4 uM for α9α10, α7β2 and α7nAChR, respectively. |
| PC-21603 |
Cris-104
α4β2 nAChR agonist
|
Cris-104 is a selective α4β2* neuronal nAChR agonist, demonstrates antinociceptive and antihypersensitivity in rodent acute/inflammatory and chronic pain models. |
| PC-21602 |
ABT-594 dihydrochloride
α4β2 nAChR agonist
|
Tebanicline dihydrochloride (ABT-594) is a potent, orally active neuronal nicotinic acetylcholine receptor (alpha 4 beta 2 nAChR) agonist with Ki of 37 pM (rat brain) and 55 pM (transfected human receptor). |
| PC-21601 |
NS9283
α4β2 nAChR PAM
|
NS9283 is a potent, positive allosteric modulator of α4β2 nAChR, acts selectively at 3α:2β stoichiometry of α2* and α4* nAChRs. |
| PC-21499 |
MK4334
α7 nAChR PAM
|
MK4334 is a potent, selective positive allosteric modulator (PAM) of the α7 nAChR with potential for treatment of Alzheimer's disease. |
| PC-21453 |
XY-4083
α7 nAChR PAM
|
XY-4083 (AVL-3288) is a selective type I α7 nAChR positive allosteric modulator (PAM), evokes positive modulation of EC5 currents induced by acetylcholine ACh, choline, and nicotine with EC50 of 0.7, 0.6 and 0.5 uM, respectively. |
