| Cat. No. |
Product Name |
Information |
| PC-63394 |
JNJ-39393406
α7 nAChR modulator
|
JNJ-39393406 is a potent, selective positive allosteric α7 nAChR modulator, potentiates a 100 μM choline-induced rise in intracellular calcium mediated by human α7 channels expressed in GH4C1 cells with EC50 of 660 nM. |
| PC-43108 |
PNU-282987
α7 nAChR agonist
|
PNU-282987 is a potent, selective α7 nAChR agonist with Ki of 26 nM, shows negligible block of α1β1γδ and α3β4 nAChRs (IC50>60 uM). |
| PC-42901 |
PNU-120596
α7 nAChR modulator
|
PNU-120596 (NSC 216666) is a potent, selective α7 nAChR positive allosteric modulator (PAM) that enhances ACh-evoked Ca2+ flux with EC50 of 216 nM, displays no activity for α3β4, α4β2 and α9β10 nAChRs. |
| PC-61620 |
ABT 089 dihydrochloride
|
ABT 089 dihydrochloride (Pozanicline) is a potent and selective α4β2 nAChR agonist with Ki of 16 nM; display selectivity over α7 nAChR (Ki>10 uM) and α1β1 nAChR. |
| PC-61619 |
ABT-089
|
ABT-089 (Pozanicline) is a potent, selective α4β2 nAChR agonist with Ki of 16 nM. |
| PC-61600 |
AQW-051
|
AQW-051 is a novel, potent and selective, orally bioavailable, brain-penetrant α7 nAChR partial agonist with pKd of 7.56. |
| PC-42788 |
ZSET1446
Acetylcholine activator
|
ZSET1446 (ST-101) is a small molecule cognitive enhancer that potentiates acetylcholine-mediated facilitation of inhibitory synaptic transmission in the hippocampal neurons. |
| PC-23179 |
SR9883
α4β2* nAChRs enhancer
|
SR9883 is a potent, selective and brain-penetrant enhanceer of α4β2* nAChRs with EC50 of 0.2-0.4 uM, shows no activity against α3β2* or α3β4* nAChRs. |
| PC-22783 |
PHA-543613
α7 nAChR agonist
|
PHA-543613 is a potent, selective agonist of alpha7 neuronal nicotinic acetylcholine receptor (α7 nAChR) with Ki of 8.8 nM, EC50 of 65 nM in cell-based FLIPR assay. |
| PC-22398 |
MB327
61368-98-7
|
MB327 is an antinicotinic bispyridinium compound, restores functional activity of nAChR. MB327 could restore soman-impaired neuromuscular function in vitro and improve survival of sarin, soman and tabun poisoned guinea pigs in vivo. |
| PC-22294 |
GAT2711
α9 nAChR agonist
|
GAT2711 is a potent, selective full agonist of α9 nAChR with EC50 of 230 nM, 340-fold selective over α7 nAChR. |
| PC-21718 |
DM506
nAChR inhibitor
|
DM506 is a novel ibogamine derivative and inhibitor of α7 and α9α10 nicotinic acetylcholine receptors (nAChRs) with IC50 of 5.1 uM, 5.6 uM and 6.4 uM for α9α10, α7β2 and α7nAChR, respectively. |
