| Cat. No. |
Product Name |
Information |
| PC-38317 |
α7nAChR PAM 28
α7 nAChR modulator
|
α7nAChR PAM 28 is a novel potent, brain-permeable, orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR) with EC50 of 0.32 uM. |
| PC-63394 |
JNJ-39393406
α7 nAChR modulator
|
JNJ-39393406 is a potent, selective positive allosteric α7 nAChR modulator, potentiates a 100 μM choline-induced rise in intracellular calcium mediated by human α7 channels expressed in GH4C1 cells with EC50 of 660 nM. |
| PC-43108 |
PNU-282987
α7 nAChR agonist
|
PNU-282987 is a potent, selective α7 nAChR agonist with Ki of 26 nM, shows negligible block of α1β1γδ and α3β4 nAChRs (IC50>60 uM). |
| PC-42901 |
PNU-120596
α7 nAChR modulator
|
PNU-120596 (NSC 216666) is a potent, selective α7 nAChR positive allosteric modulator (PAM) that enhances ACh-evoked Ca2+ flux with EC50 of 216 nM, displays no activity for α3β4, α4β2 and α9β10 nAChRs. |
| PC-61620 |
ABT 089 dihydrochloride
|
ABT 089 dihydrochloride (Pozanicline) is a potent and selective α4β2 nAChR agonist with Ki of 16 nM; display selectivity over α7 nAChR (Ki>10 uM) and α1β1 nAChR. |
| PC-61619 |
ABT-089
|
ABT-089 (Pozanicline) is a potent, selective α4β2 nAChR agonist with Ki of 16 nM. |
| PC-61600 |
AQW-051
|
AQW-051 is a novel, potent and selective, orally bioavailable, brain-penetrant α7 nAChR partial agonist with pKd of 7.56. |
| PC-42788 |
ZSET1446
Acetylcholine activator
|
ZSET1446 (ST-101) is a small molecule cognitive enhancer that potentiates acetylcholine-mediated facilitation of inhibitory synaptic transmission in the hippocampal neurons. |
| PC-23918 |
(α4)3(β2)2 nAChR PAM CMPI
(α4)3(β2)2 nAChR PAM
|
CMPI is a subtype-selective positive allosteric modulator (PAM) of nicotinic acetylcholine receptors (nAChRs), preferentially potentiates the (α4)3(β2)2 nAChR with EC50 of 0.26 uM, but not (α4)2(β2)3 nAChR isoforms. |
| PC-23864 |
GTS-21 dihydrochloride
α7 nAChR agonist
|
GTS-21 dihydrochloride (DMXBA) is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist, is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist. |
| PC-23863 |
GTS-21
α7 nAChR agonist
|
GTS-21 (DMXBA) is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist, is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.
GTS-21 (DMXBA) shows anti‑inflammatory and cognition‑enhancing activities. |
| PC-23179 |
SR9883
α4β2* nAChRs enhancer
|
SR9883 is a potent, selective and brain-penetrant enhanceer of α4β2* nAChRs with EC50 of 0.2-0.4 uM, shows no activity against α3β2* or α3β4* nAChRs. |
