| Cat. No. |
Product Name |
Information |
| PC-61600 |
AQW-051
|
AQW-051 is a novel, potent and selective, orally bioavailable, brain-penetrant α7 nAChR partial agonist with pKd of 7.56. |
| PC-42788 |
ZSET1446
Acetylcholine activator
|
ZSET1446 (ST-101) is a small molecule cognitive enhancer that potentiates acetylcholine-mediated facilitation of inhibitory synaptic transmission in the hippocampal neurons. |
| PC-21718 |
DM506
nAChR inhibitor
|
DM506 is a novel ibogamine derivative and inhibitor of α7 and α9α10 nicotinic acetylcholine receptors (nAChRs) with IC50 of 5.1 uM, 5.6 uM and 6.4 uM for α9α10, α7β2 and α7nAChR, respectively. |
| PC-21672 |
BNC210
α7 nAChR PAM
|
BNC210 (BNC 210) is a potent, selective α7 nAChR negative alteration modulator (NAM), inhibits agonist (acetylcholine) induced currents on rat and human α7 nAChRs with EC50 of 1.5 and 3 uM, respectively. |
| PC-21603 |
Cris-104
α4β2 nAChR agonist
|
Cris-104 is a selective α4β2* neuronal nAChR agonist, demonstrates antinociceptive and antihypersensitivity in rodent acute/inflammatory and chronic pain models. |
| PC-21602 |
ABT-594 dihydrochloride
α4β2 nAChR agonist
|
Tebanicline dihydrochloride (ABT-594) is a potent, orally active neuronal nicotinic acetylcholine receptor (alpha 4 beta 2 nAChR) agonist with Ki of 37 pM (rat brain) and 55 pM (transfected human receptor). |
| PC-21601 |
NS9283
α4β2 nAChR PAM
|
NS9283 is a potent, positive allosteric modulator of α4β2 nAChR, acts selectively at 3α:2β stoichiometry of α2* and α4* nAChRs. |
| PC-21499 |
MK4334
α7 nAChR PAM
|
MK4334 is a potent, selective positive allosteric modulator (PAM) of the α7 nAChR with potential for treatment of Alzheimer's disease. |
| PC-21453 |
XY-4083
α7 nAChR PAM
|
XY-4083 (AVL-3288) is a selective type I α7 nAChR positive allosteric modulator (PAM), evokes positive modulation of EC5 currents induced by acetylcholine ACh, choline, and nicotine with EC50 of 0.7, 0.6 and 0.5 uM, respectively. |
| PC-21452 |
JWX-A0108
α7 nAChR PAM
|
JWX-A0108 is a novel selective type I α7 nAChR positive allosteric modulator (PAM) with EC50 of 4.35 uM, shows no potentiation effect on α3β4 nAChR, α4β2 nAChR, or 5-HT3AR. |
| PC-21112 |
CVN417
α6 nAChR inhibitor
|
CVN417 (CVN-417) is a potent, selective and brain-penetrant α6-containing nicotinic acetylcholine receptor (α6 nAChR) antagonist with Ca2+ flux IC50 of 86 nM. |
| PC-20545 |
ABT-418 hydrochloride
nAChR activator
|
ABT-418 hydrochloride (ABT418) is an analog of (-)-nicotine and cholinergic ligand (activator) of nAChRs, a potent inhibitor of [3H]-cytisine binding to nAChR in rat brain with Ki of 2 nM. |
