| Cat. No. |
Product Name |
Information |
| PC-43404 |
RJR-2403 oxalate
|
RJR-2403 (Rivanicline, Metanicotine) is a potent, selective neuronal nicotinic ACh (nAChR) agonist with high affinity to rat brain cortex (Ki=26 nM), does not significantly activate muscle type nAChRs or muscarinic receptors. |
| PC-42900 |
A-867744
|
A-867744 is a potent, selective α7 nAChR positive allosteric modulator (PAM) with Ki of 23 nM, potentiates acetylcholine (ACh)-evoked currents with EC50 of 1 uM. |
| PC-61621 |
ABT-107
|
ABT-107 is a potent and selective α7 nAChR agonist with Ki of 0.2-0.6 nM for rat or human cortex α7 nAChRs. |
| PC-61591 |
BMS-933043
|
BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively. |
| PC-60819 |
NS3861
|
A potent, subtype-selective α3β4 nAChR partial agonist with Ki of 0.62 nM. |
| PC-60794 |
RO 5126946
|
A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM. |
| PC-60678 |
KAB-18
|
A potent, selective, noncompetitive human α4β2 nAChRs negative allosteric modulator with IC50 of 13.5 uM, displays no inhibitory activity on Hα3β4 nAChRs at 100 uM.. |
| PC-70038 |
MG-624
|
A selective antagonist of α7 nAChR that inhibits α-Bgtx binding to α7 with Ki of 106 nM. |
| PC-45968 |
Galanthamine
|
A potent allosteric potentiating ligand of human nAChRs α4β2, α3β4, and α6β4. |
