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Request The Product List ofγ-secretase γ-secretase

Cat. No. Product Name Information
PC-36082

BMS-932481

γ-secretase modulator

BMS-932481 (BMS932481) is a potent, selective, orraly active γ-secretase modulator (GSM), shows selectivity for Aβ40 and Aβ42 reduction (IC50=6.6 nM) while sparing total Aβ levels both in vitro and in vivo.
PC-43337

DAPT

γ-secretase inhibitor

DAPT (GSI-IX, GSI IX) is a small molecule γ-secretase inhibitor that reduces the total beta-amyloid peptide (Aβ) production with IC50 of 20 nM in HEK 293 cells, without affecting protein secretion.
PC-42810

RO4929097

RO4929097 (RG 4733) is a potent, selective, orally active γ-secretase inhibitor with IC50 of 4 nM, inhibits Notch processing in the Notch cell-based reporter assay with IC50 of 5 nM.
PC-62921

MRK-560

γ-secretase inhibitor

MRK-560 is a potent, brain-penetrant and orally bioavailable γ-secretase inhibitor that inhibits proteolytic cleavage of APP over the Notch pathway.
PC-42758

MK-0752

γ-secretase inhibitor

MK-0752 (MK0752) is a potent γ-secretase inhibitor that shows dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells, inhibits Notch signaling.
PC-49410

Nirogacestat

γ-secretase inhibitor

Nirogacestat (PF-03084014) is a potent, noncompetitive, and selective gamma-secretase inhibitor, reduces amyloid-beta (Abeta) production with in vitro IC50 of 1.2 nM (whole-cell assay) to 6.2 nM (cell-free assay).
PC-72151

RO7185876

gamma secretase modulator

RO7185876 (RO 7185876) is a potent and selective gamma secretase modulator (GSM) with IC50 Aβ42 of 2 nM.
PC-35276

LY900009

LY900009 (LY-900009) is an orally active small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein, inhibits Notch signalling in tumour cell lines and endothelial cells with IC50 of 0.005-20 nM.
PC-35198

BPN-15606

BPN-15606 (BPN15606) is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 by SHSY5Y neuroblastoma cells with IC50 of 7 nM.
PC-35113

GSM-1

GSM-1 (GSM1) is a γ-secretase modulator that directly targets the transmembrane domain (TMD) 1 of presenilin 1, shows potent Aβ42-lowering effect (IC50=0.348 uM) in a cell-based assay.
PC-43045

Z-Ile-Leu-aldehyde

Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) is a potent gamma-secretase and Notch signaling inhibitor.
PC-62920

AZ 4800

AZ 4800 is a potent γ-secretase modulator that reduces Aβ40 and Aβ42 levels in HEK/APPswe cells with IC50 of 26 nM and 60 nM, also decreases Aβ39, whereas increases both Aβ37 and Aβ38..

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