| Cat. No. |
Product Name |
Information |
| PC-43534 |
AZD3839
BACE1 inhibitor
|
AZD3839 (AZD-3839, AZD 3839) is a potent and selective BACE1 inhibitor with Ki of 26 nM, displays 14- and >1000-fold selectivity against BACE2 and cathepsin D. |
| PC-63380 |
LY3202626
BACE inhibitor
|
LY3202626 (LY-3202626) is a highly potent, CNS-penetrant, orally available BACE inhibitor with IC50 of 239 nM. |
| PC-63290 |
PF-06751979
BACE1 inhibitor
|
PF-06751979 is a potent, selective, brain penetrant BACE1 inhibitor with binding IC50 of 7.3, 27-fold selectivity over BACE2. |
| PC-43420 |
LY2886721
BACE1 inhibitor
|
LY2886721 (LY-2886721) is a highly potent, selective BACE1 aspartyl protease inhibitor with IC50 of 20.3 and 10.2 nM for BACE1 and BACE2, shows no inhibition against cathepsin D, pepsin, renin, or other aspartyl proteases. |
| PC-61044 |
RO5508887
BACE inhibitor
|
RO5508887 (RG7129) is a potent, selective BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM) but >1,000-fold selectivity over cathepsin D, cathepsin E, pepsin and renin. |
| PC-61042 |
TAK-070
BACE1 inhibitor
|
TAK-070 (TAK070) is a selective, nonpeptidic, noncompetitive BACE1 inhibitor with IC50 of 3.15 uM in cell-free assays. |
| PC-60507 |
Atabecestat
BACE inhibitor
|
Atabecestat (JNJ-54861911, JNJ54861911) is a novel potent beta-secretase (BACE) inhibitor for treatment of Alzheimer's Disease. |
| PC-60085 |
CNP-520
BACE1 inhibitor
|
Umibecestat (CNP520) is a potent, selective, and efficacious β-Secretase (BACE1) inhibitor with IC50 of 11 nM and 30 nM for BACE1 and BACE2, respectively. |
| PC-60084 |
Elenbecestat
BACE1 inhibitor
|
Elenbecestat (E2609) is a novel potent, oral BACE1 inhibitor for treatment of Alzheimer's disease. |
| PC-60045 |
Lanabecestat
BACE1 inhibitor
|
Lanabecestat (AZD-3293, LY-3314814) is a potent, orally active and brain-permeable BACE1 inhibitor with Ki of 0.4 nM. |
| PC-45073 |
Verubecestat
BACE inhibitor
|
Verubecestat (MK-8931) is a potent, selective, structurally unique BACE inhibitor with Ki of 2.2 nM and 0.38 nM for BACE1 and BACE2, respectively. |
| PC-73095 |
AM-6494
BACE1 inhibitor
|
AM-6494 (AM6494) is a potent and orally efficacious BACE1 inhibitor with IC50 of 0.4 nM, 47 fold selectivity over BACE2. |
