| Cat. No. |
Product Name |
Information |
| PC-20786 |
RG108
DNMT inhibitor
|
RG108 (N-Phthalyl-L-tryptophan) is small molecule that effectively blocks DNA methyltransferases (DNMT) in vitro (IC50=115 nM) and does not cause covalent enzyme trapping in human cell lines. |
| PC-49682 |
NSC232003
UHRF1 inhibitor
|
NSC232003 is a small molecule inhibitor of ubiquitin-like protein UHRF1, bind the 5-methylcytosine pocket of UHRF1 and inhibit its functionality, reduces DNMT1/UHRF1 interactions in U251 glioma cells with IC50 of 15 uM, induces global DNA cytosine demethylation. |
| PC-49681 |
UF146
UHRF1 inhibitor
|
UF146 (UF-146) is a specific small molecule inhibitor of ubiquitin-like protein UHRF1, binds with the SRA domain groove of UHRF1 with KD of 3.71 uM, significantly inhibits the binding of UHRF1 and hemi-methylated DNA with IC50 of 499.4 nM in FRET assays. |
| PC-38486 |
SW155246
DNMT1 inhibitor
|
SW155246 is a potent, selective antagonis/inhibitor of DNA methyltransferase DNMT1 with IC50 of 1.2 uM against hDNMT1, 30-fold preference versus human or murine DNMT3A or -3B (IC50=38 uM). |
| PC-73377 |
GSK3543105
DNMT1 inhibitor
|
GSK3543105 is a potent, selective, non-nucleoside inhibitor of DNMT1 with IC50 of 33 nM. |
| PC-73376 |
GSK3735967
DNMT1 inhibitor
|
GSK3735967 is a potent, selective, non-nucleoside inhibitor of DNMT1 with IC50 of 40 nM. |
| PC-72377 |
UHRF1 PHD inhibitor MLD4
UHRF1 inhibitor
|
UHRF1 PHD inhibitor MLD4 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=12.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger. |
| PC-72376 |
UHRF1 PHD inhibitor MLD5
UHRF1 inhibitor
|
UHRF1 PHD inhibitor MLD5 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=7.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger. |
| PC-72251 |
2,4-lutidine
UHRF1 inhibitor
|
2,4-lutidine is a small molecule targeting the UHRF1 tandem Tudor domain (TTD) with TR-FRET (His6-TTD vs. H3K9me3) EC50 of 29.2 uM. |
| PC-72250 |
F1957-0088
UHRF1 inhibitor
|
F1957-0088 is a small molecule targeting the UHRF1 tandem Tudor domain (TTD) with TR-FRET (TTD vs. H3K9me3) EC50 of 45.1 uM. |
| PC-72249 |
5A-DMP
UHRF1 inhibitor
|
5A-DMP is a novel TTD-binding compound that binds to tandem Tudor domain (TTD) of UHRF1, inhibits the full-length UHRF1: LIG1 interaction in Xenopus egg extracts. |
| PC-72248 |
UHRF1 inhibitor UM63
UHRF1 inhibitor
|
UHRF1 inhibitor UM63 (UM63) is an anthraquinone compound that binds to the 5-methylcytosine (5mC) binding pocket of the SRA domain of UHRF1, inhibits the base-flipping process, which is crucial in the replication of DNA methylation profiles. |
