| Cat. No. |
Product Name |
Information |
| PC-23839 |
TYRA-300
FGFR3 inhibitor
|
Dabogratinib (TYRA-300) is a potent, selective and oral FGFR3 inhibitor with IC50 of 11 nM in in Ba/F3 cells, 14-fold seletive over FGFR2 and >20-fold over FGFR1, FGFR4. |
| PC-22316 |
LHQ490
FGFR2 inhibitor
|
LHQ490 is a potent, highly selective fibroblast growth factor receptor 2 (FGFR2) inhibitor with Ic50 of 5.2 nM, >61-, >34-, and >293-fold selective against FGFR1, FGFR3, and FGFR4. |
| PC-21612 |
DW14383
FGFR inhibitor
|
DW14383 is a potent, selective and irreversible inhibitor of FGFR1-4 with IC50 of <0.3 nM, 1.1 nM, <0.3 nM and 0.5 nM for FGFR1/2/3/4 respectively. |
| PC-21538 |
ABSK011
FGFR4 inhibitor
|
Irpagratinib (ABSK011) is a potent, selective FGFR4 inhibitor with strong antitumor activity against hepatocellular carcinoma (HCC). |
| PC-20046 |
RLY-4008
FGFR2 inhibitor
|
Lirafugratinib (RLY-4008, RYL4008) is a potent, highly selective and irreversible FGFR2 inhibitor with biochemical IC50 of <100 nM, shows high cellular potency (IC50=6 nM, pFGFR; pERK, IC50=3 nM). |
| PC-49580 |
FRS2 ligand 7
FRS2 inhibitor
|
FRS2 ligand 7 is a small molecule ligand of the PTB domain of FGFR proximal adaptor protein FRS2, prevents FRS2 activation and interrupts FGFR signaling, inhibits invasion and tumor growth. |
| PC-49450 |
FGFR2/3 inhibitor 29
FGFR2/3 inhibitor
|
FGFR2/3 inhibitor 29 is a potent and selective inhibitor of FGFR2/3 wild-type and gatekeeper mutant with IC50 of 1 nM and 0.5 nM for FGFR2 and FGFR3, respectively. |
| PC-38509 |
PD089828
FGFR inhibitor
|
PD089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR with IC50 of 0.15 uM, 1.76 uM, and 5.47 uM, respectively. |
| PC-38477 |
Alphastatin-C
bFGF inhibitor
|
Alphastatin-C is a 14-amino acids peptide consisting of a C-terminal fragment of the α-chain of Fgn, is a potent inhibitor of bFGF induced endothelial cell (HUVEC-CS) activation in vitro. |
| PC-38396 |
Gunagratinib
FGFR inhibitor
|
ICP-192 (Gunagratinib) is a novel potent, covalent pan-FGFR (fibroblast growth factor receptors) inhibitor, potently and selectively inhibits FGFR activities irreversibly by covalent binding. |
| PC-73227 |
CXF-009
FGFR4 inhibitor
|
CXF-009 is a potent, specific, dual-warhead covalent inhibitor of FGFR4 (IC50=48 nM), forms dual-warhead covalent bonds with two cysteine residues in FGFR4. |
| PC-72411 |
MAX-40279
FLT3/FGFR inhibitor
|
MAX-40279 (MAX40279, EX-A4057) is a dual inhibitor of FLT3 and FGFR for the treatment of Acute Myeloid Leukemia (AML). |
