| Cat. No. |
Product Name |
Information |
| PC-21365 |
Talnetant
NK3R antagonist
|
Talnetant (SB223412) is a potent, selective, competitive and brain-permeable neurokinin-3 receptor (NK3R) antagonist with Ki of 1.4 nM in hNK-3-CHO cells. |
| PC-38599 |
Tradipitant
NK1R antagonist
|
Tradipitant (VLY-686, LY686017) is a selective, orally bioavailable, centrally-acting neurokinin-1 receptor (NK1) antagonist with potential anti-emetic, anti-pruritic and anti-inflammatory activities. |
| PC-35774 |
NY0128
NMUR2 agonist
|
NY0128 (NY 0128) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 29.99 uM for hNMUR1 and 10.30 uM for hNMUR2 in intracellular calcium mobilization assays. |
| PC-35773 |
NY0116
NMUR2 agonist
|
NY0116 (NY 0116) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 27.76 uM for hNMUR1 and 13.61 uM for hNMUR2 in intracellular calcium mobilization assays. |
| PC-63390 |
Serlopitant
NK1R antagonist
|
Serlopitant (VPD-737, MK-0594) is a potent, selective substance P/neurokinin 1 (NK1) receptor for treating chronic pruritus. |
| PC-63134 |
Senktide
NK3R antagonist
|
Senktide is a potent, selective agonist of neuromedin K3 (NK3) receptor (EC50 =0.5-3 nM), less potently agonizes the NK1 receptor (EC50=35 µM) and is without effect on the NK2 receptor. |
| PC-63098 |
GR-64349
NK2R agonist
|
GR-64349 is a potent and selective tachykinin NK2 receptor (NK2R) agonist with EC50 of 3.7 nM, displays >1000- and >300-fold selectivity over NK1 and NK3 receptors, respectively. |
| PC-62979 |
Maropitant citrate
NK1 receptor antagonist
|
Maropitant citrate (Cerenia) is a selective neurokinin 1 receptor (NK1) antagonist for prevention of vomiting due to motion sickness in dogs.. |
| PC-62976 |
GR-73632
NK1 receptor agonist
|
GR-73632 is a potent and selective tachykinin NK1 receptor agonist with EC50 of 2 nM, promotes differentiation but not survival of rat chromaffin cells in vitro. |
| PC-61581 |
Casopitant mesylate
NK1R antagonist
|
Casopitant (GW679769) mesylate is a potent, selective, orally active, and brain penetrant neurokinin 1 (NK1) receptor antagonist with pKi of 9.48. |
| PC-61580 |
Casopitant
NK1R antagonist
|
Casopitant (GW679769) is a potent, selective, orally active, and brain penetrant neurokinin 1 (NK1) receptor antagonist with pKi of 9.48. |
| PC-61579 |
Vestipitant mesylate
NK1 receptor antagonist
|
Vestipitant (GW597599) mesylate is a potent, selective, orally active NK1 receptor antagonist with pKi of 9.65. |
