Cat. No. |
Product Name |
Information |
PC-38430 |
Zastaprazan
Gastric H+/K+-ATPase inhibitor
|
Zastaprazan (JP-1366) is a potent selective inhibitor of gastric H+/K+-ATPase activity with IC50 of 16.7 nM, >400-fold selectivity over Na+/K+-ATPase activity. |
PC-72574 |
Verucopeptin
V-ATPase inhibitor
|
Verucopeptin (BS-1152) is a cyclodepsipeptide with notable antitumor potency, directly taregts ATP6V1G, a subunit of the vacuolar H+-ATPase (v-ATPase). |
PC-38295 |
2GBI
Hv1 channel inhibitor
|
2GBI (2-guanidinobenzimidazole) is a guanidine derivative that inhibits voltage-gated proton channel Hv1 by binding to the VSD from its intracellular side.. |
PC-38294 |
YHV98-4
Hv1 channel inhibitor
|
YHV98-4 is a selective inhibitor of proton-selective ion channel Hv1 with IC50 of 0.7 uM. |
PC-63544 |
Diphyllin
V-ATPase inhibitor
|
Diphyllin is a naturally potent vacuolar ATPase (v-ATPase) inhibitor with IC50 of 17 nM, potently inhibits the acid influx with IC50 of 0.6 nM. |
PC-62141 |
BRD1240
|
BRD1240 is a small-molecule probe that can suppress V-ATPase function, inhibits lysosomal acidification and blocks the maturation of autophagosomes to autolysosomes. |
PC-60826 |
TAK-438
|
TAK-438 (Vonoprazan) is a novel potent, potassium-competitive acid blocker (P-CAB) that inhibits H(+),K(+)-ATPase activity in porcine gastric microsomes with IC50 of 19 nM at pH 6.5. |
PC-60811 |
Tegoprazan
|
Tegoprazan (CJ 12420, RQ-00000004, RQ-4) is a novel potent, highly selective, competitive and orally active inhibitor of gastric H+/K+-ATPase with IC50 of ranging 0.29-0.52 uM porcine, canine and human H+/K+-ATPases in vitro. |
PC-45146 |
Esomeprazole sodium
Proton pump inhibitor
|
Esomeprazole sodium is a proton pump inhibitor that reduces stomach acid secretion by inhibition of the H+/K+-ATPase in the parietal cells. |
PC-22177 |
Bafilomycin A1
V-ATPase inhibitor
|
Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H+-ATPase (V-ATPase) with IC50 of 4-400 nM, also is an autophagy inhibitor, blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes. |
PC-73426 |
Linaprazan glurate
Proton Pump inhibitor
|
Linaprazan glurate (X-842) is a proton pump inhibitor with potential for treatment of oesophagitis. |
PC-72018 |
Hv1 inhibitor HIF
Hv1 channel inhibitor
|
Hv1 inhibitor HIF is a novel inhibitor of the voltage-gated proton channel Hv1 interacts with the Hv1 VSD in the up and down states. |