| Cat. No. |
Product Name |
Information |
| PC-47029 |
BW-031 chloride
Nav1.7 inhibitor
|
BW-031 chloride is a potent cationic sodium channel inhibitor, inhibits Nav 1.7 (IC50=9.5 uM) and Nav 1.1 channels with approximately sixfold greater potency than QX-314. |
| PC-38662 |
ABBV-318
Nav1.7/ Nav1.8 blocker
|
ABBV-318 is a small molecule voltage-gated sodium channel Nav1.7/ Nav1.8 blocker with IC50 of 3.8 and 2.8 uM for hNav1.7 and hNav1.8 in FRET assays, respectively. |
| PC-38569 |
DPI 201-106
Na+ channel opener
|
DPI 201-106 (SDZ 201106) is a positive inotropic agent that prolongs the open state of cardiac voltage-gated Na+ channels. |
| PC-38398 |
Idrevloride
ENaC inhibitor
|
Idrevloride (P-1037) is a potent, selective epithelial sodium channel (ENaC) blocker with potential for the treatment of skin disorders. |
| PC-73408 |
Bliretrigine
Sodium Channel inhibitor
|
Bliretrigine is a sodium channel blocker with the effect of relieving pain. |
| PC-73335 |
ASIC1a inhibitor 5b
ASIC1a inhibitor
|
ASIC1a inhibitor 5b is a highly selective and potent ASIC1a inhibitor, inhibits proton-evoked ASIC1a currents with an apparent IC50 of 27 nM at pH 6.7. |
| PC-73334 |
Psalmotoxin 1
ASIC1a inhibitor
|
Psalmotoxin 1 (PcTx1) is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker with IC50 of 0.9 nM. |
| PC-73070 |
XPC-6444
NaV1.6 inhibitor
|
XPC-6444 (XPC6444) is a potent, CNS-penetrant, isoform-selective NaV1.6 inhibitor with IC50 of 41 nM, also potently blocks NaV1.2 (IC50=125 nM). |
| PC-72898 |
BI 1265162
ENaC inhibitor
|
BI 1265162 is a potent ENaC inhibitor, inhibits Na+ transport with IC50 3 nM and 8 nM in M1 and NCI-H441 cells, respectively. |
| PC-72850 |
NBI-921352
NaV1.6 inhibitor
|
NBI-921352 (XEN901, NBI 921352) is a potent, highly selective, orally active inhibitor of NaV1.6 with IC50 of 51 nM (hNaV1.6 channel currents inhibition). |
| PC-72811 |
AZ194
CRMP2-Ubc9 inhibitor
|
AZ194 (CRMP2-Ubc9 inhibitor 194) is a potent and selective inhibitor of NaV1.7 currents in DRG neurons via inhibition of the CRMP2-Ubc9 interaction. |
| PC-72674 |
PRAX-562
Persistent INa inhibitor
|
PRAX-562 (PRAX562) is a novel persistent sodium current (INa) inhibitor, inhibits hNaV1.6 persistent INa induced by ATX-II or SCN8A mutation N1768D with IC50 of 141 and 75 nM, respectively. |
