| Cat. No. |
Product Name |
Information |
| PC-73335 |
ASIC1a inhibitor 5b
ASIC1a inhibitor
|
ASIC1a inhibitor 5b is a highly selective and potent ASIC1a inhibitor, inhibits proton-evoked ASIC1a currents with an apparent IC50 of 27 nM at pH 6.7. |
| PC-73334 |
Psalmotoxin 1
ASIC1a inhibitor
|
Psalmotoxin 1 (PcTx1) is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker with IC50 of 0.9 nM. |
| PC-73070 |
XPC-6444
NaV1.6 inhibitor
|
XPC-6444 (XPC6444) is a potent, CNS-penetrant, isoform-selective NaV1.6 inhibitor with IC50 of 41 nM, also potently blocks NaV1.2 (IC50=125 nM). |
| PC-72898 |
BI 1265162
ENaC inhibitor
|
BI 1265162 is a potent ENaC inhibitor, inhibits Na+ transport with IC50 3 nM and 8 nM in M1 and NCI-H441 cells, respectively. |
| PC-72850 |
NBI-921352
NaV1.6 inhibitor
|
NBI-921352 (XEN901, NBI 921352) is a potent, highly selective, orally active inhibitor of NaV1.6 with IC50 of 51 nM (hNaV1.6 channel currents inhibition). |
| PC-72811 |
AZ194
CRMP2-Ubc9 inhibitor
|
AZ194 (CRMP2-Ubc9 inhibitor 194) is a potent and selective inhibitor of NaV1.7 currents in DRG neurons via inhibition of the CRMP2-Ubc9 interaction. |
| PC-72674 |
PRAX-562
Persistent INa inhibitor
|
PRAX-562 (PRAX562) is a novel persistent sodium current (INa) inhibitor, inhibits hNaV1.6 persistent INa induced by ATX-II or SCN8A mutation N1768D with IC50 of 141 and 75 nM, respectively. |
| PC-72209 |
SSCI-2
Nav1.7 inhibitor
|
SSCI-2 is a highly potent, selective NaV1.7 inhibitor with IC50 of 9 and 17 nM on human and rhesus Nav1.7 channels, respectively. |
| PC-72208 |
SSCI-1
Nav1.7 inhibitor
|
SSCI-1 is a highly potent, selective NaV1.7 inhibitor with IC50 of 27 and 82 nM on human and rhesus Nav1.7 channels, respectively. |
| PC-72207 |
NaV1.7 inhibitor 51
Nav1.7 inhibitor
|
NaV1.7 inhibitor 51 is a highly potent, selective, orally active NaV1.7 inhibitor with IC50 of 10.7 nM in FLIPR membrane potential assay, no significant activity against NaV1.5 (IC50>10 uM). |
| PC-72206 |
ProTx II
NaV1.7 inhibitor
|
ProTx II (Protoxin II) is a selective NaV1.7 channel blocker with IC50 of 0.3 nM, 100-fold selectivity over other sodium channel subtypes. |
| PC-72205 |
DA-0218
Nav1.7 inhibitor
|
DA-0218 (DA0218) is a novel potent, selective Nav1.7 inhibitor, inhibits sodium currents in Nav1.7-expressing human embryonic kidney 293 cells with IC50 of 0.74 uM. |
