| Cat. No. |
Product Name |
Information |
| PC-45252 |
Flecainide acetate
Nav1.5 inhibitor, RyR2 inhibitor
|
A class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential. |
| PC-27210 |
Nav1.5 inhibitor KH2
Nav1.5 inhibitor
|
Nav1.5 inhibitor KH2 is an effective Nav1.5 inhibitor with IC50 of 1.38 uM, reduces cardiac conduction. |
| PC-27185 |
Lamotrigine
CAS 84057-84-1
|
Lamotrigine (BW430C) is a potent and orally active anticonvulsant and antiepileptic agent, selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. |
| PC-27184 |
Tetracaine
RyR inhibitor, Nav1.7 inhibitor
|
Tetracaine (Amethocaine) is a sodium channel inhibitor and ryanodine receptor (RyR) inhibitor, blocks sodium conduction across nerve cell membranes, preventing rapid sodium ion influx and depolarization. |
| PC-27183 |
TC-N1752
NaV1.7 inhibitor
|
TC-N1752 is a potent, state-dependent and orally active inhibitor of voltage gated sodium channel Nav1.7 with IC50 of 0.17 uM, 0.3 uM, 0.4 uM, 1.1 uM and 2.2 uM for hNav1.7, hNav1.3, hNav1.4, hNaV1.5 and rNav1.8, respectively, displays analgesic efficacy in the formalin pain model. |
| PC-26991 |
Rufinamide
Nav1.1 blocker
|
Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na+ current activation, limits the firing of sodium-dependent action potentials in neurons, functions as a Nav1.1 channel blocker. |
| PC-26525 |
S3226
NHE3 inhibitor
|
S3226 is a potent, selective Na+/H+ exchanger subtype 3 (NHE3, SLC9A3) inhibitor with IC50 of 0.02 uM (hNHE3), shows >100-fold selectivity over hNHE1 and rbNHE2. |
| PC-26470 |
AM-2099
NaV1.7 inhibitor
|
AM-2099 is a potent, selective inhibitor of voltage-gated sodium channel NaV1.7 with IC50 of 0.16 uM (hNaV1.7), with no actiivity against hNaV1.5. |
| PC-26048 |
Eleclazine
I(Na,late) inhibitor
|
Eleclazine (GS6615) hydrochloride is a potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF). |
| PC-25144 |
GSK3β-Nav1.6 inhibitor 1063
GSK3β/Nav1.6 inhibitor
|
GSK3β-Nav1.6 inhibitor 1063 is a brain-penetrant small molecule that selectively disrupts GSK3β/Nav1.6 complex formation (IC50=26.2 uM) and inhibits Nav1.6 currents in an isoform-specific manner. |
| PC-25089 |
Repunapanor
NHE3 inhibitor
|
Repunapanor is a potent, selective Na+/H+ exchanger 3 (NHE3) inhibitor. |
| PC-25070 |
ZL192
FGF13/Nav1.7 inhibitor
|
ZL192 is a small molecule FGF13 ligand / activator and a positive modulator of FGF13/Nav1.7 complex, stabilizes FGF13/Nav1.7 CTD assembly with EC50 of 28 uM, sensitizes Na+ currents in hIPSC-derived sensory neurons. |
