| Cat. No. |
Product Name |
Information |
| PC-24162 |
Olisutrigine bromide
Sodium channel blocker
|
Olisutrigine bromide (EN3427) is a novel permanently charged cationic sodium channel blocker, produces effective and long-lasting analgesia in rodent pain models. |
| PC-24070 |
E0199
NaV inhibitor, Kv7 activator
|
E0199 is a dual-targeting inhibitor of NaV1.7, NaV1.8, and NaV1.9 and activator of KV7 channels with IC50 of 0.52 uM (NaV1.7), 0.24 uM (NaV1.8), 0.16 uM (NaV1.9), and EC50 of 0.5 uM/12.78 nM/0.19 uM for KV7.2, KV7.2/7.3 and KV7.4 channels. |
| PC-24050 |
Nav1.7 inhibitor WN2-R
Nav1.7 inhibitor
|
Nav1.7 inhibitor WN2-R is a novel potent, selective Nav1.7 antagonist with IC50 of 24.7 nM within the VSDIV pocket of Nav1.7. |
| PC-23790 |
Compound 1028
FGF14/Nav1.6 modulator
|
Compound 1028 is a potent, brain-permeable small molecule that targets FGF14 R117 with binding KD of 293 nM (SPR), selectively modulates FGF14/Nav1.6 complex assembly and depolarizes the voltage-dependence of Nav1.6 channel inactivation. |
| PC-23761 |
Phenamil methanesulfonate
ENaC inhibitor
|
Phenamil methanesulfonate is a potent, reversible epithelial sodium channel (ENaC) blocker with IC50 of 400 nM, is also a competive inhibitor of TRPP3 and inhibits TRPP3-mediated Ca2+ transport with IC50 of 140 nM in Ca2+ uptake assay. |
| PC-23672 |
Amiloride
ENaC inhibitor
|
Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC and urokinase-type plasminogen activator receptor (uTPA), also is a blocker of polycystin-2 (PC2, TRPP2) channel. |
| PC-23587 |
Nav1.8 inhibitor 42
Nav1.8 inhibitor
|
Nav1.8 inhibitor 42 is a potent, selective Nav1.8 inhibitor with IC50 of 35 nM (human Nav1.8), shows weak actiivty against mouse Nav1.8 (IC50=3040 nM). |
| PC-23533 |
NaV1.7 inhibitor 31
Nav1.7 inhibitor
|
NaV1.7 inhibitor 31 is a potent and selective inhibitor of Nav1.7 with Ki/IC50 of 4.9 nM/13 nM (hNav1.7), >400-fold selective over hNav1.5. |
| PC-23462 |
ETD001
ENaC inhibitor
|
ETD001 is a potent, selective epithelial sodium channel (ENaC) inhibitor with IC50 of 57 nM. |
| PC-22308 |
QLS-81
Nav1.7 inhibitor
|
QLS-81 is a potent, selective Nav1.7 channel inhibitor with IC50 of 3.5 uM for inhibition of Nav1.7 current in whole-cell patch-clamp recording assay. |
| PC-21839 |
S3969
ENaC activator
|
S3969 is a small molecule activator of the human epithelial sodium channel (ENaC) with EC50 of 1.2 uM in ENaC-expressing oocytes. |
| PC-21711 |
UTX-143
NHE5 inhibitor
|
UTX-143 is a potent, selective sodium-hydrogen exchange subtype 5 (NHE5) inhibitor with IC50 of 3.11 uM, 80-fold selective over NHE1. |
