| Cat. No. |
Product Name |
Information |
| PC-43094 |
Tetrodotoxin
Sodium channel blocker
|
Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6. |
| PC-42355 |
PF-01247324
Nav1.8 inhibitor
|
PF-01247324 is a potent, selective and orally active Nav1.8 channel blocker with IC50 of 196 nM, inhibits native TTX-R currents in human DRG neurons with IC50 of 331 nM. |
| PC-63176 |
PF-05150122
NaV1.7 inhibitor
|
PF-05150122 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5. |
| PC-63175 |
PF-05198007
NaV1.7 inhibitor
|
PF-05198007 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 9 nM, with no significant activity against Nav1.5 (IC50>10 uM). |
| PC-63166 |
PF-05089771
Nav1.7 inhibitor
|
PF-05089771 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 11 nM, >1,000-fold selectivity over Nav1.3, 1.4 and Nav1.5, 1.8. |
| PC-63155 |
AZD7009
Nav1.5 inhibitor
|
AZD7009 is an antiarrhythmic agent that inhibits the late sodium current in CHO K1 cells expressing hNav1.5 with IC50 of 11 uM. |
| PC-63154 |
AZD-1305
S
|
AZD-1305 is a novel antiarrhythmic agent that predominantly blocks the rapid component of IKr, the L-type calcium current, and the inward sodium current in mammalian cells and ventricular cardiomyocytes. |
| PC-63147 |
Tenapanor
NHE3 inhibitor
|
Tenapanor (AZD-1722, RDX5791) is a potent, selective inhibitor of the Na+/H+ exchanger 3 (NHE3) with IC50 of 5 and 10 nM for human and rat NHE3, respectively. |
| PC-63146 |
Tenapanor hydrochloride
NHE3 inhibitor
|
Tenapanor (AZD-1722, RDX5791) hydrochloride is a potent, selective inhibitor of the Na+/H+ exchanger 3 (NHE3) with IC50 of 5 and 10 nM for human and rat NHE3, respectively. |
| PC-62718 |
GS-462808
Nav1.5 inhibitor
|
GS-462808 is a potent Late INa current inhibitor of the cardiac Nav1.5 channel with IC50 of 1.33 uM. |
| PC-62647 |
Diminazene aceturate
ASIC1a inhibitor
|
Diminazene aceturate is an anti-infective agent, also is a slow pore blocker of acid-sensing ion channel 1a (ASIC1a) with IC50 of 0.3 uM. |
| PC-62325 |
GNE-0439
Nav1.7 inhibitor
|
GNE-0439 is a novel potent, selective inhibitor of Nav1.7 channel with IC50 of 0.34 uM, shows high selectivity over Nav1.5 (IC50=38.3 uM). |
