| Cat. No. |
Product Name |
Information |
| PC-61854 |
AZD-3161
NaV1.7 inhibitor
|
AZD-3161 (AZD3161) is a potent and selective sodium channel Nav1.7 blocker with pIC50 of 7.1, >100-fold selective over NaV1.5. |
| PC-61853 |
PF-04856264
NaV1.7 inhibitor
|
PF-04856264 is a potent, selective Nav1.7 blocker with IC50 of 28 nM, dispalys >1,000-fold selectivity over Nav1.5. |
| PC-61336 |
Lacosamide
Sodium channel inhibitor
|
Lacosamide (SPM 927) is an anticonvulsant compound that enhances the slow inactivation of voltage-gated sodium channels without affecting the fast inactivation of voltage-gated sodium channels. |
| PC-60629 |
AMG 8379
NaV1.7 inhibitor
|
AMG 8379 (AMG-8379, AMG8379) is a potent and selective voltage-gated sodium channel Nav1.7 antaognist with IC50 of 8.5 nM. |
| PC-70213 |
Flecainide
Nav1.5 inhibitor, RyR2 inhibitor
|
Flecainide is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential. |
| PC-60194 |
AnCoA4
Orai1 channel inhibitor
|
AnCoA4 (AnCoA-4, Jamaicin) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM. |
| PC-60005 |
A-317567
|
A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM. |
| PC-47508 |
Benzocaine
Sodium channel inhibitor
|
Benzocaine is a local anesthetic, inhibits voltage-dependent sodium channels (VDSCs) on the neuron membrane, stopping the propagation of the action potential. |
| PC-45927 |
Proparacaine hydrochloride
Sodium channel inhibitor
|
Proparacaine hydrochloride (Proxymetacaine hydrochloride) is an irreversible local anesthetic, inhibits pain sensations that is believed to act as an antagonist on voltage-gated sodium channels. |
| PC-45625 |
Nav1.7-IN-2
NaV1.7 inhibitor
|
Nav1.7-IN-2 is a potent, selective inhibitor of voltage-gated sodium channel Nav1.7 (IC50=80 nM), extracts from patent WO/2011103196 A1, compound example J. |
| PC-45224 |
Ranolazine dihydrochloride
Sodium channel inhibitor
|
Ranolazine dihydrochloride is an anti-ischemic agent that has been shown to inhibit late I(Na) and I(Kr) and to have antiarrhythmic effects in various preclinical in vitro models. |
| PC-42318 |
ETH2120
Sodium ionophore
|
ETH2120 is a sodium ionophore, relieves hydrogen-dependent caffeate reduction and completely abolishes ATP synthesis in cells. |
