| Cat. No. |
Product Name |
Information |
| PC-26899 |
ICA604025
Nav1.9 inhibitor
|
ICA604025 is a potent, selective sodium channel Nav1.9 subtype inhibitor, inhibits human Nav1.9 in a state dependent manner with EC50s of 9 nM and 1.1 μM for the activated/inactivated state versus resting closed state. |
| PC-26880 |
MK-5661
Nav1.8 inhibitor
|
MK-5661 (MK5661) is a potent, selective, and orally bioavailable NaV1.8 inhibitor with EC50 of 4.3 nM. |
| PC-26654 |
ZL141
GSK3β/Nav1.6 inhibitor
|
ZL141 is a peptidomimetic that disrupts GSK3β/Nav1.6 CTD complex formation with IC50 of 20 uM, does not affect the kinase activity of GSK3β, ZL141 binds to GSK3β with SPR KD of 15.9 uM. |
| PC-25532 |
ICA00600232
Nav1.1 potentiator
|
ICA00600232 is a potent, selective small molecule Nav1.1 sodium channel potentiator with EC50 of 24 nM, exhibits >1000-fold selectivity for human Nav1.1 over all other Nav1.x family members except Nav1.3 (EC50=98 nM). |
| PC-25069 |
PW164
FGF13/Nav1.7 inhibitor
|
PW164 is a specific, small molecule inhibitor of FGF13/Nav1.7 channel C-terminal tail domain (CTD) PPI interface with IC50 of 29 uM (FGF13/Nav1.7 complex assembly), selectively modulates Nav1.7 currents. |
| PC-25007 |
Vormatrigine
Persistent INa inhibitor, NaV blocker
|
Vormatrigine (PRAX-628) is a potent and activity dependent inhibitor of persistent and peak sodium current (INa) with IC50 of 128 nM, a NaV blocker with greater potency and preference for persistent INa. |
| PC-23790 |
Compound 1028
FGF14/Nav1.6 modulator
|
Compound 1028 is a potent, brain-permeable small molecule that targets FGF14 R117 with binding KD of 293 nM (SPR), selectively modulates FGF14/Nav1.6 complex assembly and depolarizes the voltage-dependence of Nav1.6 channel inactivation. |
| PC-23139 |
MSD199 hydrochloride
Nav1.8 inhibitor
|
MSD199 hydrochloride is a potent, and selective Nav1.8 inhibitor with IC50 of 4.7 nM in Qube automated patch-clamp assay, >2000-fold selective over all other Nav isoforms. |
| PC-23138 |
MSD199
Nav1.8 inhibitor
|
MSD199 is a potent, and selective Nav1.8 inhibitor with IC50 of 4.7 nM in Qube automated patch-clamp assay, >2000-fold selective over all other Nav isoforms. |
| PC-22639 |
VX-548
NaV1.8 inhibitor
|
VX-548 (Suzetrigine) is a potent, highly selective and orally bioavailable inhibitor of NaV1.8 voltage-gated sodium channel with IC50 of 0.7 nM. |
| PC-22573 |
VX-150
NaV1.8 inhibitor
|
VX-150 (VX150) is a highly selective, orally bioavailable NaV1.8 channel inhibitor, shows >400-fold selectivity over other sodium channel subtypes. |
| PC-22424 |
ANP-230
Nav1.7/1.8/1.9 inhibitor
|
ANP-230 (DSP-2230) is a selective sodium channel blocker of human Nav1.7, Nav1.8, and Nav1.9 with IC50 of 7.1, 11.4, and 6.7 μM (sodium currents), shows only low inhibitory activity to human cardiac Nav1.5 channel and rat central Nav channels. |
