| Cat. No. |
Product Name |
Information |
| PC-42201 |
Nicainoprol
Sodium channels inhibitor
|
A sodium channels blocker, adrenergic receptor antagonist and class 1 antiarrhythmic agent.. |
| PC-42621 |
PH-064
|
PH-064 (BIM-46187) is an inhibitor of heterotrimeric G-protein complex. |
| PC-45079 |
ICA-121431
Nav1.3/Nav1.1 inhibitor
|
A potent, selective small molecule human Nav1.3/Nav1.1 channel inhibitor with IC50 of 19 nM. |
| PC-45762 |
XEN-907
NaV1.7 inhibitor
|
XEN-907 (XEN907) is a potent, selective NaV1.7 blocker with IC50 of 3 nM. |
| PC-42804 |
A-803467
Nav1.8 inhibitor
|
A-803467 (A803467) potent and selective Nav1.8 sodium channel blocker with IC50 of 8 nM. |
| PC-45068 |
Eleclazine hydrochloride
Sodium channel inhibitor
|
A novel, potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF). |
| PC-45252 |
Flecainide acetate
Nav1.5 inhibitor, RyR2 inhibitor
|
A class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential. |
| PC-22639 |
VX-548
NaV1.8 inhibitor
|
VX-548 (Suzetrigine) is a potent, highly selective and orally bioavailable inhibitor of NaV1.8 voltage-gated sodium channel with IC50 of 0.7 nM. |
| PC-22573 |
VX-150
NaV1.8 inhibitor
|
VX-150 is a highly selective, orally bioavailable NaV1.8 channel inhibitor, shows >400-fold selectivity over other sodium channel subtypes, induces analgesia in a variety of evoked pain tests, without affecting subject safety. |
| PC-22424 |
ANP-230
Nav1.7/1.8/1.9 inhibitor
|
ANP-230 (DSP-2230) is a selective sodium channel blocker of human Nav1.7, Nav1.8, and Nav1.9 with IC50 of 7.1, 11.4, and 6.7 μM (sodium currents), shows only low inhibitory activity to human cardiac Nav1.5 channel and rat central Nav channels. |
| PC-22308 |
QLS-81
Nav1.7 inhibitor
|
QLS-81 is a potent, selective Nav1.7 channel inhibitor with IC50 of 3.5 uM for inhibition of Nav1.7 current in whole-cell patch-clamp recording assay. |
| PC-21839 |
S3969
ENaC activator
|
S3969 is a small molecule activator of the human epithelial sodium channel (ENaC) with EC50 of 1.2 uM in ENaC-expressing oocytes. |
