| Cat. No. |
Product Name |
Information |
| PC-72192 |
GDC-0276
NaV1.7 inhibitor
|
GDC-0276 (GDC 0276) is a highly potent, selective NaV1.7 inhibitor with IC50 of with binding Ki of 1.1 nM (hNaV1.7), cellular sodium influx IC50 of 49 nM. |
| PC-72191 |
GDC-0310
NaV1.7 inhibitor
|
GDC-0310 (GDC 0310 ) is a highly potent, selective NaV1.7 inhibitor with IC50 of with binding Ki of 1.8 nM (hNaV1.7), cellular sodium influx IC50 of 16 nM. |
| PC-72189 |
DS-1971a
NaV1.7 inhibitor
|
DS-1971a (DS1971a) is a highly potent, selective NaV1.7 inhibitor with IC50 of 22.8 nM (hNaV1.7) and 59.4 nM (mNaV1.7). |
| PC-38297 |
BI-8668
ENaC inhibitor
|
BI-8668 (BI 8668) is a highly potent and selective epithelial sodium channel (ENaC) inhibitor, inhibits Na+ current with IC50 of 17 nM (Ussing chamber assay). |
| PC-36160 |
GNE-616
NaV1.7 inhibitor
|
GNE-616 (GNE616) is a highly potent, metabolically stable, subtype selective inhibitor of Nav1.7 with Ki of 0.79 nM (hNav1.7). |
| PC-36104 |
Voluloride
ENaC inhibitor
|
Voluloride is a conjunctival epithelial cell sodium channel (ENaC) blocker.. |
| PC-35885 |
PF-06305591
Nav1.8 inhibitor
|
PF-06305591 (PF06305591) is a potent, highly selective selective NaV1.8 blocker with IC50 of 15 nM, displays no significant activity against other sodium channel subtypes, K+ channels and Ca2+ channels. |
| PC-35155 |
PF-05661014
Nav1.3 inhibitor
|
PF-05661014 is a potent, selective Nav1.3 inhibitor with IC50 of 0.26 uM, shows no activity for Nav1.7 (IC50>10 uM). |
| PC-35154 |
PF-06526290
Nav1.3 inhibitor
|
PF-06526290 is a potent, selective Nav1.3 inhibitor with IC50 of 5.1 uM, interact with the Domain 4 voltage sensor domain (D4 VSD and shows no activity for Nav1.7. |
| PC-35118 |
VGSC blocker 4
Nav1.5 inhibitor
|
VGSC blocker 4 is a potent, small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5), blocks INa peak currents 25% at 1 uM. |
| PC-35117 |
VGSC blocker 1
Nav1.5 inhibitor
|
VGSC blocker 1 is a potent, small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5), blocks INa peak currents 34.9% at 1 uM. |
| PC-35103 |
GNE-131
NaV1.7 inhibitor
|
GNE-131 is a potent, selective inhibitor of sodium channel NaV1.7 with IC50 of 3 nM, >80-fold selectivity over the cardiac sodium channel NaV1.5. |
