| Cat. No. |
Product Name |
Information |
| PC-35053 |
KR-33028
NHE1 inhibitor
|
KR-33028 is a potent, highly selective NHE1 inhibitor with IC50 of 2.59 uM. |
| PC-35052 |
Cariporide
|
Cariporide (HOE642) is a potent, selective sodium-hydrogen exchange subtype 1 (NHE1) inhibitor with IC50 of 50 nM, shows little to no activity against NHE3 and NHE2 (IC50=3 and 10 uM). |
| PC-35034 |
BI-9627
NHE1 inhibitor
|
BI-9627 is a potent, selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1) with pHi change IC50 of 6 nM, displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. |
| PC-63534 |
SPX-101
ENaC inhibitor
|
SPX-101 is a specific, peptide mimetic promoter of epithelial sodium channel (ENaC) internalization, binds selectively to ENaC and promotes internalization of the α-, β-, and γ-subunits. |
| PC-63263 |
GpTx-1
NaV1.7 inhibitor
|
GpTx-1 is a potent, selective, 34-residue peptide antagonist of Nav1.7 sodium channel with IC50 of 10 nM, displays 20- and 1000- fold selectivity over NaV1.4 and NaV1.5.. |
| PC-43216 |
CNV1014802 hydrochloride
NaV1.7 inhibitor
|
CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine) is a potent, selective Nav1.7 sodium channel blocker, shows analgesic effects and potential in the treatment of cognitive symptoms of schizophrenia in vivo.. |
| PC-43215 |
CNV1014802
Nav1.7 inhibitor
|
CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine, BIIB074) is a potent, selective Nav1.7 sodium channel blocker, shows analgesic effects and potential in the treatment of cognitive symptoms of schizophrenia in vivo. |
| PC-43116 |
GS967
Nav1.5 inhibitor
|
GS-458967 (GS967) is a potent, selective inhibitor of cardiac late sodium current (late INa), inhibits TX-II-induced late INa in ventricular myocytes and isolated hearts with IC50 of 0.13 and 0.21 uM, respectively. |
| PC-43094 |
Tetrodotoxin
Sodium channel blocker
|
Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6. |
| PC-42355 |
PF-01247324
Nav1.8 inhibitor
|
PF-01247324 is a potent, selective and orally active Nav1.8 channel blocker with IC50 of 196 nM, inhibits native TTX-R currents in human DRG neurons with IC50 of 331 nM. |
| PC-63176 |
PF-05150122
NaV1.7 inhibitor
|
PF-05150122 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5. |
| PC-63175 |
PF-05198007
NaV1.7 inhibitor
|
PF-05198007 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 9 nM, with no significant activity against Nav1.5 (IC50>10 uM). |
