| Cat. No. |
Product Name |
Information |
| PC-63166 |
PF-05089771
Nav1.7 inhibitor
|
PF-05089771 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 11 nM, >1,000-fold selectivity over Nav1.3, 1.4 and Nav1.5, 1.8. |
| PC-63155 |
AZD7009
Nav1.5 inhibitor
|
AZD7009 is an antiarrhythmic agent that inhibits the late sodium current in CHO K1 cells expressing hNav1.5 with IC50 of 11 uM. |
| PC-63154 |
AZD-1305
S
|
AZD-1305 is a novel antiarrhythmic agent that predominantly blocks the rapid component of IKr, the L-type calcium current, and the inward sodium current in mammalian cells and ventricular cardiomyocytes. |
| PC-63147 |
Tenapanor
|
Tenapanor (AZD-1722, RDX5791) is a potent, selective inhibitor of the Na+/H+ exchanger 3 (NHE3) with IC50 of 5 and 10 nM for human and rat NHE3, respectively |
| PC-63146 |
Tenapanor hydrochloride
|
Tenapanor (AZD-1722;RDX5791) is a potent, selective inhibitor of the Na+/H+ exchanger 3 (NHE3) with IC50 of 5 and 10 nM for human and rat NHE3, respectively. |
| PC-62718 |
GS-462808
Nav1.5 inhibitor
|
GS-462808 is a potent Late INa current inhibitor of the cardiac Nav1.5 channel with IC50 of 1.33 uM. |
| PC-62325 |
GNE-0439
Nav1.7 inhibitor
|
GNE-0439 is a novel potent, selective inhibitor of Nav1.7 channel with IC50 of 0.34 uM, shows high selectivity over Nav1.5 (IC50=38.3 uM). |
| PC-62324 |
GX-936
NaV1.7 inhibitor
|
GX-936 (PF 05196233) is a potent Nav1.7 inhibitor that binds to the activated state of voltage-sensor domain IV (VSD4), exhibits robust inhibition of the 1KαPMTX-evoked N1742K response with IC50 of 40 nM. |
| PC-62323 |
GX-674
Nav1.7 inhibitor
|
GX-674 is a potent, selective Nav1.7 inhibitor with IC50 of 0.1 nM. |
| PC-61870 |
PF-04531083
Nav1.8 inhibitor
|
PF-04531083 (PF 4531083) is a potent and selective, orally available sodium channel Nav1.8 blocker for treatment of pain. |
| PC-61869 |
XEN-402
|
XEN-402 (Funapide,TV-45070) is a potent and selective, orally available sodium channel Nav1.7 and Nav1.8 blocker for treatment of pain. |
| PC-61857 |
PF-05241328
NaV1.7 inhibitor
|
PF-05241328 (PF 5241328) is a potent and selective, orally active inhibitor of voltage-dependent sodium channel Nav1.7 with IC50 of 31 nM. |
