| Cat. No. |
Product Name |
Information |
| PC-45252 |
Flecainide acetate
Nav1.5 inhibitor, RyR2 inhibitor
|
A class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential. |
| PC-23587 |
Nav1.8 inhibitor 42
Nav1.8 inhibitor
|
Nav1.8 inhibitor 42 is a potent, selective Nav1.8 inhibitor with IC50 of 35 nM (human Nav1.8), shows weak actiivty against mouse Nav1.8 (IC50=3040 nM). |
| PC-23533 |
NaV1.7 inhibitor 31
Nav1.7 inhibitor
|
NaV1.7 inhibitor 31 is a potent and selective inhibitor of Nav1.7 with Ki/IC50 of 4.9 nM/13 nM (hNav1.7), >400-fold selective over hNav1.5. |
| PC-23462 |
ETD001
ENaC inhibitor
|
ETD001 is a potent, selective epithelial sodium channel (ENaC) inhibitor with IC50 of 57 nM. |
| PC-22639 |
VX-548
NaV1.8 inhibitor
|
VX-548 (Suzetrigine) is a potent, highly selective and orally bioavailable inhibitor of NaV1.8 voltage-gated sodium channel with IC50 of 0.7 nM. |
| PC-22573 |
VX-150
NaV1.8 inhibitor
|
VX-150 is a highly selective, orally bioavailable NaV1.8 channel inhibitor, shows >400-fold selectivity over other sodium channel subtypes, induces analgesia in a variety of evoked pain tests, without affecting subject safety. |
| PC-22308 |
QLS-81
Nav1.7 inhibitor
|
QLS-81 is a potent, selective Nav1.7 channel inhibitor with IC50 of 3.5 uM for inhibition of Nav1.7 current in whole-cell patch-clamp recording assay. |
| PC-21839 |
S3969
ENaC activator
|
S3969 is a small molecule activator of the human epithelial sodium channel (ENaC) with EC50 of 1.2 uM in ENaC-expressing oocytes. |
| PC-21779 |
XPC-5462
NaV1.2/1.6 inhibitor
|
XPC-5462 is a potent, selective dual inhibitor of NaV1.6 and NaV1.2 with IC50 of 10.9 nM and 10.3 nM, respectively. |
| PC-21778 |
XPC-7224
NaV1.6 inhibitor
|
XPC-7224 is a potent, selective NaV1.6 inhibitor with IC50 of 78 nM and 130 nM for human and mouse NaV1.6, respectively, interacts with the inactivated state of the channel. |
| PC-21711 |
UTX-143
NHE5 inhibitor
|
UTX-143 is a potent, selective sodium-hydrogen exchange subtype 5 (NHE5) inhibitor with IC50 of 3.11 uM, 80-fold selective over NHE1. |
| PC-21230 |
Aneratrigine
Sodium Channel inhibitor
|
Aneratrigine is a sodium channel protein type 9 subunit alpha blocker. |
