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Cat. No. Product Name Information
PC-45068

Eleclazine hydrochloride

Sodium current inhibitor

A novel, potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF).
PC-45252

Flecainide acetate

Nav1.5 inhibitor, RyR2 inhibitor

A class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential.
PC-23790

Compound 1028

FGF14/Nav1.6 modulator

Compound 1028 is a potent, brain-permeable small molecule that targets FGF14 R117 with binding KD of 293 nM (SPR), selectively modulates FGF14/Nav1.6 complex assembly and depolarizes the voltage-dependence of Nav1.6 channel inactivation.
PC-23761

Phenamil methanesulfonate

ENaC inhibitor

Phenamil methanesulfonate is a potent, reversible epithelial sodium channel (ENaC) blocker with IC50 of 400 nM, is also a competive inhibitor of TRPP3 and inhibits TRPP3-mediated Ca2+ transport with IC50 of 140 nM in Ca2+ uptake assay.
PC-23672

Amiloride

ENaC inhibitor

Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC and urokinase-type plasminogen activator receptor (uTPA), also is a blocker of polycystin-2 (PC2, TRPP2) channel.
PC-23587

Nav1.8 inhibitor 42

Nav1.8 inhibitor

Nav1.8 inhibitor 42 is a potent, selective Nav1.8 inhibitor with IC50 of 35 nM (human Nav1.8), shows weak actiivty against mouse Nav1.8 (IC50=3040 nM).
PC-23533

NaV1.7 inhibitor 31

Nav1.7 inhibitor

NaV1.7 inhibitor 31 is a potent and selective inhibitor of Nav1.7 with Ki/IC50 of 4.9 nM/13 nM (hNav1.7), >400-fold selective over hNav1.5.
PC-23462

ETD001

ENaC inhibitor

ETD001 is a potent, selective epithelial sodium channel (ENaC) inhibitor with IC50 of 57 nM.
PC-22573

VX-150

NaV1.8 inhibitor

VX-150 is a highly selective, orally bioavailable NaV1.8 channel inhibitor, shows >400-fold selectivity over other sodium channel subtypes, induces analgesia in a variety of evoked pain tests, without affecting subject safety.
PC-22308

QLS-81

Nav1.7 inhibitor

QLS-81 is a potent, selective Nav1.7 channel inhibitor with IC50 of 3.5 uM for inhibition of Nav1.7 current in whole-cell patch-clamp recording assay.
PC-21839

S3969

ENaC activator

S3969 is a small molecule activator of the human epithelial sodium channel (ENaC) with EC50 of 1.2 uM in ENaC-expressing oocytes.
PC-21779

XPC-5462

NaV1.2/1.6 inhibitor

XPC-5462 is a potent, selective dual inhibitor of NaV1.6 and NaV1.2 with IC50 of 10.9 nM and 10.3 nM, respectively.

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