| Cat. No. |
Product Name |
Information |
| PC-45079 |
ICA-121431
Nav1.3/Nav1.1 inhibitor
|
ICA-121431 is a potent, selective small molecule human Nav1.3/Nav1.1 channel inhibitor with IC50 of 19 nM. |
| PC-45762 |
XEN-907
NaV1.7 inhibitor
|
XEN-907 (XEN907) is a potent, selective NaV1.7 blocker with IC50 of 3 nM. |
| PC-42804 |
A-803467
Nav1.8 inhibitor
|
A-803467 (A803467) potent and selective Nav1.8 sodium channel blocker with IC50 of 8 nM. |
| PC-45068 |
Eleclazine hydrochloride
Sodium current inhibitor
|
A novel, potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF). |
| PC-45252 |
Flecainide acetate
Nav1.5 inhibitor, RyR2 inhibitor
|
A class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential. |
| PC-25089 |
Repunapanor
NHE3 inhibitor
|
Repunapanor is a potent, selective Na+/H+ exchanger 3 (NHE3) inhibitor. |
| PC-25070 |
ZL192
FGF13/Nav1.7 inhibitor
|
ZL192 is a small molecule FGF13 ligand / activator and a positive modulator of FGF13/Nav1.7 complex, stabilizes FGF13/Nav1.7 CTD assembly with EC50 of 28 uM, sensitizes Na+ currents in hIPSC-derived sensory neurons. |
| PC-25069 |
PW164
FGF13/Nav1.7 inhibitor
|
PW164 is a specific, small molecule inhibitor of FGF13/Nav1.7 channel C-terminal tail domain (CTD) PPI interface with IC50 of 29 uM (FGF13/Nav1.7 complex assembly), selectively modulates Nav1.7 currents. |
| PC-25010 |
NaV1.6 inhibitor Compound 103
NaV1.6 inhibitor
|
NaV1.6 inhibitor Compound 103 is a potent, selective voltage-gated sodium channel NaV1.6 inhibitor with IC50 of 61 nM, >400-fold selective over NaV1.1 and NaV1.5. |
| PC-25007 |
Vormatrigine
Persistent INa inhibitor, NaV blocker
|
Vormatrigine (PRAX-628) is a potent and activity dependent inhibitor of persistent and peak sodium current (INa) with IC50 of 128 nM, a NaV blocker with greater potency and preference for persistent INa. |
| PC-24889 |
Methocarbamol
Nav1.4 inhibitor
|
Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channe, reversibly affects voltage dependence of inactivation of Nav1.4 channel. |
| PC-24199 |
Zilvetrigine
Sodium channel inhibitor
|
Zilvetrigine is a potent, selective sodium channel inhibitor with potential for treatment of pain. |
