Cat. No. |
Product Name |
Information |
PC-21291 |
TopBP1 inhibitor 5D4
TopBP1
|
TopBP1 inhibitor 5D4 is a small-molecule inhibitor of TopBP1 (topoisomerase IIβ-binding protein 1), specifically targets the BRCT7/8 domains of TopBP1, blocks MYC activity by freeing MIZ1, a MYC inhibitor, from TopBP1. |
PC-49220 |
VPC-70063
c-Myc inhibitor
|
VPC-70063 (VPC70063) is a small molecule Myc inhibitor that inhibits Myc-Max transcriptional activity with IC50 of 8.9 uM in c-Myc luciferase reporter assay in LNCaP cells, disrupts the interaction of Myc-Max with DNA. |
PC-47053 |
D089
Myc inhibitor
|
D089 is a selective small molecule stabilizer of the MYC G4-quadruplex, not only inhibits MYC expression in myeloma cell lines, but also selectively induces G1 arrest in MYC-driven cancer cell lines containing the MYC-G4 sequence. |
PC-38435 |
3JC48-3
c-Myc inhibitor
|
3JC48-3 is a potent, cellularly active and stable c-Myc inhibitor, inhibits c-Myc-max dimerization with IC50 of 34 uM, 5 times more potent than 10074-G5, exhibits an approximate twofold selectivity for c-Myc-Max heterodimers over Max-Max homodimers. |
PC-73228 |
MYCMI-7
MYC-MAX inhibitor
|
MYCMI-7 is a small molecule MYC-binding compound (Kd=4 uM) that inhibits MYC-MAX interaction. |
PC-73127 |
MYCi975
c-Myc inhibitor
|
MYCi975 (NUCC-0200975) is a close analog of MYCi361 with improved therapeutic index, binds to MYC protein with KD of 2.5 uM, disrupts MYC/MAX complex formation. |
PC-73126 |
MYCi361
MYC inhibitor
|
MYCi361 (NUCC-0196361) is a small molecule MYC inhibitor, binds to MYC protein with KD of 3.2 uM, disrupts MYC/MAX complex formation. |
PC-72931 |
VPC-70619
N-Myc inhibitor
|
VPC-70619 (VPC70619) is a selective small-molecule inhibitor of N-Myc transcription in NMYC transcription inhibition assays. |
PC-35303 |
MYCMI-6
MYC-MAX inhibitor
|
MYCMI-6 (NSC354961) is a selective, high affinity inhibitor of MYC-MAX interaction, blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with Kd of 1.6 uM in SPR assay. |
PC-35075 |
APTO-253
KLF4 inducer
|
APTO-253 is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels. |
PC-43158 |
10058-F4
c-Myc inhibitor
|
10058-F4 is a specific c-Myc inhibitor that disrupts the association between the c-Myc and Max, inhibits HL60 cell growth with IC50 of 51 uM. |
PC-61358 |
IRES-J007
IRES inhibitor
|
IRES-J007 is an improved IRES inhibitor that blocks IRES-hnRNP A1 binding, binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11). |