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Cat. No. Product Name Information
PC-21291

TopBP1 inhibitor 5D4

TopBP1

TopBP1 inhibitor 5D4 is a small-molecule inhibitor of TopBP1 (topoisomerase IIβ-binding protein 1), specifically targets the BRCT7/8 domains of TopBP1, blocks MYC activity by freeing MIZ1, a MYC inhibitor, from TopBP1.
PC-49220

VPC-70063

c-Myc inhibitor

VPC-70063 (VPC70063) is a small molecule Myc inhibitor that inhibits Myc-Max transcriptional activity with IC50 of 8.9 uM in c-Myc luciferase reporter assay in LNCaP cells, disrupts the interaction of Myc-Max with DNA.
PC-47053

D089

Myc inhibitor

D089 is a selective small molecule stabilizer of the MYC G4-quadruplex, not only inhibits MYC expression in myeloma cell lines, but also selectively induces G1 arrest in MYC-driven cancer cell lines containing the MYC-G4 sequence.
PC-38435

3JC48-3

c-Myc inhibitor

3JC48-3 is a potent, cellularly active and stable c-Myc inhibitor, inhibits c-Myc-max dimerization with IC50 of 34 uM, 5 times more potent than 10074-G5, exhibits an approximate twofold selectivity for c-Myc-Max heterodimers over Max-Max homodimers.
PC-73228

MYCMI-7

MYC-MAX inhibitor

MYCMI-7 is a small molecule MYC-binding compound (Kd=4 uM) that inhibits MYC-MAX interaction.
PC-73127

MYCi975

c-Myc inhibitor

MYCi975 (NUCC-0200975) is a close analog of MYCi361 with improved therapeutic index, binds to MYC protein with KD of 2.5 uM, disrupts MYC/MAX complex formation.
PC-73126

MYCi361

MYC inhibitor

MYCi361 (NUCC-0196361) is a small molecule MYC inhibitor, binds to MYC protein with KD of 3.2 uM, disrupts MYC/MAX complex formation.
PC-72931

VPC-70619

N-Myc inhibitor

VPC-70619 (VPC70619) is a selective small-molecule inhibitor of N-Myc transcription in NMYC transcription inhibition assays.
PC-35303

MYCMI-6

MYC-MAX inhibitor

MYCMI-6 (NSC354961) is a selective, high affinity inhibitor of MYC-MAX interaction, blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with Kd of 1.6 uM in SPR assay.
PC-35075

APTO-253

KLF4 inducer

APTO-253 is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels.
PC-43158

10058-F4

c-Myc inhibitor

10058-F4 is a specific c-Myc inhibitor that disrupts the association between the c-Myc and Max, inhibits HL60 cell growth with IC50 of 51 uM.
PC-61358

IRES-J007

IRES inhibitor

IRES-J007 is an improved IRES inhibitor that blocks IRES-hnRNP A1 binding, binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11).

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