| Cat. No. |
Product Name |
Information |
| PC-21497 |
RGH-560
α7 nAChR PAM
|
RGH-560 (RGH560) is a potent, selective α7 nAChR positive allosteric modulator (PAM) with EC50 of 190 nM (Ca2+-influx). |
| PC-21112 |
CVN417
α6 nAChR inhibitor
|
CVN417 (CVN-417) is a potent, selective and brain-penetrant α6-containing nicotinic acetylcholine receptor (α6 nAChR) antagonist with Ca2+ flux IC50 of 86 nM. |
| PC-49428 |
AT1001
α3β4 nAChR inhibitor
|
AT1001 (AT-1001) is a high affinity and selective α3β4 nAChR antagonist with Ki value of 2.4 nM, >90-fold selectivity over the other major subtypes (α4β2 and α7 nAChR). |
| PC-49027 |
AN317
α6β2 nAChR agonist
|
AN317 is a functionally selective, partial agonist of α6β2-containing nicotinic acetylcholine receptor (nAChR) with pEC50 of 7.17 (α6/α3β2β3V9'S receptor) in cell-based assays, inhibits the effect of nicotine with IC50 of 1.1 uM. |
| PC-38681 |
Simpinicline
nAChR agonist
|
Simpinicline (OC-02) is a highly selective nicotinic acetylcholine receptor (nAChR) agonist, exhibits potent antiviral activity against the SARS-CoV-2 variants in cell culture with IC50 of 40 nM. |
| PC-38475 |
4BP-TQS
α7 nAChR agonist
|
4BP-TQS (GAT107 racemic) is a potent, selective, allosteric agonist of α7 nAChRs with EC50 of 17 uM, no activity for α1β1δε-, α3β4-, and α4β2 subunit-containing nAChRs at 100 uM. |
| PC-73326 |
ATA-101
α7 nAChR agonist
|
ATA-101 (Tc-5619, Bradanicline) is a potent, highly selective, CNS-penetrant α7 nicotinic receptor (α7 nAChR) agonist. |
| PC-73036 |
RGM079
α7 nACh PAM
|
RGM079 (RGM-079) is a potent, selective α7 nAChR positive allosteric modulator (PAM) with EC50 of 8.3 uM. |
| PC-73023 |
BNC375
α7 nAChR PAM
|
BNC375 (BNC-375) is a potent, selective, orally available type I α7 nAChR positive allosteric modulator (PAM) with EC50 of 1.3 uM. |
| PC-72282 |
TC-6683
α4β2 nAChR agonist
|
TC-6683 (AZD1446) is a potent and highly selective α4β2 nAChR agonist with Ki of 30/34 nM against hα4β2/rα4β2, with little to no affinity against h α3β2 and h α7 (Ki>6.7 uM). |
| PC-72170 |
AP-202
α4β2 antagonist
|
AP-202 (AP202) is a highly potent and selective α4β2 nAChR antagonist with binding Ki of 18 nM, 57-fold selectivity over α3β4 receptor. |
| PC-72169 |
SUVN-911
α4β2 antagonist
|
SUVN-911 (Ropanicant) is a novel, potent, selective, orally active α4β2 nAChR receptor antagonist with Ki of 1.5 nM. |
