| Cat. No. |
Product Name |
Information |
| PC-21497 |
RGH-560
α7 nAChR PAM
|
RGH-560 (RGH560) is a potent, selective α7 nAChR positive allosteric modulator (PAM) with EC50 of 190 nM (Ca2+-influx). |
| PC-49027 |
AN317
α6β2 nAChR agonist
|
AN317 is a functionally selective, partial agonist of α6β2-containing nicotinic acetylcholine receptor (nAChR) with pEC50 of 7.17 (α6/α3β2β3V9'S receptor) in cell-based assays, inhibits the effect of nicotine with IC50 of 1.1 uM. |
| PC-73326 |
ATA-101
α7 nAChR agonist
|
ATA-101 (Tc-5619, Bradanicline) is a potent, highly selective, CNS-penetrant α7 nicotinic receptor (α7 nAChR) agonist. |
| PC-73036 |
RGM079
α7 nACh PAM
|
RGM079 (RGM-079) is a potent, selective α7 nAChR positive allosteric modulator (PAM) with EC50 of 8.3 uM. |
| PC-73023 |
BNC375
α7 nAChR PAM
|
BNC375 (BNC-375) is a potent, selective, orally available type I α7 nAChR positive allosteric modulator (PAM) with EC50 of 1.3 uM. |
| PC-72169 |
SUVN-911
α4β2 antagonist
|
SUVN-911 (Ropanicant) is a novel, potent, selective, orally active α4β2 nAChR receptor antagonist with Ki of 1.5 nM. |
| PC-38317 |
α7nAChR PAM 28
α7 nAChR modulator
|
α7nAChR PAM 28 is a novel potent, brain-permeable, orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR) with EC50 of 0.32 uM. |
| PC-63394 |
JNJ-39393406
α7 nAChR modulator
|
JNJ-39393406 is a potent, selective positive allosteric α7 nAChR modulator, potentiates a 100 μM choline-induced rise in intracellular calcium mediated by human α7 channels expressed in GH4C1 cells with EC50 of 660 nM. |
| PC-43108 |
PNU-282987
α7 nAChR agonist
|
PNU-282987 is a potent, selective α7 nAChR agonist with Ki of 26 nM, shows negligible block of α1β1γδ and α3β4 nAChRs (IC50>60 uM). |
| PC-42901 |
PNU-120596
α7 nAChR modulator
|
PNU-120596 (NSC 216666) is a potent, selective α7 nAChR positive allosteric modulator (PAM) that enhances ACh-evoked Ca2+ flux with EC50 of 216 nM, displays no activity for α3β4, α4β2 and α9β10 nAChRs. |
| PC-61620 |
ABT 089 dihydrochloride
|
ABT 089 dihydrochloride (Pozanicline) is a potent and selective α4β2 nAChR agonist with Ki of 16 nM; display selectivity over α7 nAChR (Ki>10 uM) and α1β1 nAChR. |
| PC-61619 |
ABT-089
|
ABT-089 (Pozanicline) is a potent, selective α4β2 nAChR agonist with Ki of 16 nM. |
