| Cat. No. |
Product Name |
Information |
| PC-35318 |
BRD1991
Beclin 1/Bcl-2 inhibitor
|
BRD1991 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity.. |
| PC-35317 |
SW076956
Beclin 1/Bcl-2 inhibitor
|
SW076956 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity.. |
| PC-35316 |
SW063058
Beclin 1/Bcl-2 inhibitor
|
SW063058 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity.. |
| PC-43514 |
Apogossypol
BCL-2 inhibitor
|
Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively. |
| PC-63502 |
S55746
BCL-2 inhibitor
|
S55746 (BCL201, Servier-1) is a novel potent, selective, orally bioavailable inhibitor of BCL-2 with Ki of 1.3 nM, 70- 400 fold selectivity over BCL-XL, on significant binding to MCL-1 and BFL-1. |
| PC-63501 |
S55746 hydrochloride
BCL-2 inhibitor
|
S55746 (BCL201, Servier-1) hydrochloride is a novel potent, selective, orally bioavailable inhibitor of BCL-2 with Ki of 1.3 nM, 70- 400 fold selectivity over BCL-XL, on significant binding to MCL-1 and BFL-1. |
| PC-43235 |
Mcl1-IN-2
Mcl-1 inhibitor
|
Mcl1-IN-2 (IMB-XH1) is an Mcl-1 inhibitor without a reported IC50 value, also is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor with IC50 of 0.46 uM. |
| PC-63211 |
Sabutoclax
BCL-2 inhibitor
|
Sabutoclax (BI-97C1) is a potent, pan Bcl-2 family proteins inhibitor that inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31, 0.32, 0.20 and 0.62 uM. |
| PC-43096 |
Pyridoclax
Mcl-1 inhibitor
|
Pyridoclax (MR29072) is a highly potent Mcl-1 inhibitor with Kd of 25 nM, disrupts Mcl-1/Bim interaction. |
| PC-43048 |
A-1210477
Mcl-1 inhibitor
|
A-1210477 is a potent, selective Mcl-1 inhibitor that bind to Mcl-1 (Ki=0.45 nM) to disrupt MCL-1-BIM complexes, shows much weaker against Bcl-2 (Ki=132 nM) and Bcl-XL (Ki>660 nM). |
| PC-42836 |
TW-37
Bcl-2 inhibitor
|
TW-37 is a potent, nonpeptidic small-molecule inhibitor of Bcl-2 with Ki of 290 nM, also binds to Bcl-xL and Mcl-1 with high affinities. |
| PC-42826 |
HA14-1
Bcl-2 inhibitor
|
HA14-1 a small molecule, nonpeptidic Bcl-2 antagonist that binds Bcl-2 surface pocket with binding IC50 of 9 uM, induces apoptosis of tumor cells. |
