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Cat. No. Product Name Information
PC-24290

WEHI-3773

VDAC2-BAX inhibitor

WEHI-3773 is a small molecule inhibitor of interaction between VDAC2 and BAX, inhibits apoptosis mediated by BAX by blocking VDAC2-mediated BAX recruitment to mitochondria.
PC-24151

Lonitoclax

BCL-2 inhibitor

Lonitoclax is a potent, selective next generation BCL-2 inhibitor, a key pro-survival protein that is overexpressed in many cancers, for the treatment of AML and CLL.
PC-23978

Bcl-3 inhibitor A27

Bcl-3 inhibitor

Bcl-3 inhibitor A27 is a specific small molecule inhibitor of proto-oncogene Bcl-3, inhibits Bcl-3-mediated cyclin D1 expression and promoter activity, affects the binding between Bcl-3 and the NF-κB transcription factor p50, without affecting the classical NF-κB activation.
PC-23835

AMG-397

Mcl-1 inhibitor

Murizatoclax (AMG-397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor with Ki of 15 pM.
PC-23834

ABBV-467

Mcl-1 inhibitor

ABBV-467 is a highly potent and selective MCL-1 inhibitor with TR-FRET Ki of <0.01 nM, >25,000-fold seletive over other BCL-2 family proteins BCL-XL, BCL-2, BCL-W, and BCL2-A1.
PC-23607

BFL1 inhibitor 20

BFL1 inhibitor

BFL1 inhibitor 20 is a potent, selective, covalent and orally bioavailable BFL1 inhibitor with IC50 of 19 nM in TR-FRET assays, binds to Cys55 of BFL1.
PC-23094

Lacutoclax

Bcl-2 inhibitor

Lacutoclax (LP-108) is a highly potent and selective inhibitor of BCL-2 with comparable or more potent in vitro inhibitory activity compared to venetoclax.
PC-23065

Bfl-1 inhibitor (R,R,S)-26

Bfl-1 inhibitor

Bfl-1 inhibitor (R,R,S)-26 is a potent, selective, covalent, cell active Bfl-1 inhibitor with IC50 of 22 nM, shows no activity against Bcl-xl, Bcl-2 and Mcl-1 (IC50>30 uM).
PC-22977

BRD-810

Mcl-1 inhibitor

BRD-810 is a potent and selective MCL1 inhibitor with IC50 of 0.3 nM in AMO-1 cells, potently binds to the BH3 groove of MCL1 protein.
PC-22111

TUDCA

Bax inhibitor

Tauroursodeoxycholic acid (TUDCA) is a neuroprotective bile conjugate, prevents Bax translocation both in vitro and in vivo, thereby preserving mitochondrial function and suppressing apoptosis.
PC-22106

BAM7

Bax activator

BAM7 is a selective Bax activator,, competes with FITC-BIM SAHB for BAX binding with IC50 of 3.3 uM, activates BAX and BAX-dependent cell death.
BAM7 is selective for the BH3-binding site on BAX.
PC-22105

CBI1

Bax inhibitor

Covalent BAX inhibitor 1 (CBI1) is a specific, covalent BAX inhibitor selectively derivatizes BAX at Cys126 and inhibits BAX activation by triggering ligands or point mutagenesis.

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